This $450,526 Project Grant was awarded on June 1, 2024 by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research at Northwestern University to discover novel transcriptional programs that regulate T cell exhaustion, a key mechanism underlying persistent viral infections and cancer.
The research aims to leverage single-cell sequencing and CRISPR/Cas9 gene editing technologies to screen a set of computationally selected transcription factors and rapidly validate their biological function in regulating CD8 T cell differentiation and cell fate decisions. The goal is to gain new insights into the transcriptional regulation of T cell exhaustion, which can inform the development of innovative therapeutic approaches to treat chronic viral infections and cancer. The project will be conducted over a 2-year period ending on April 30, 2026.
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