This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $812,603 to develop selective calcium-dependent protein kinase 1 (CDPK1) inhibitors for the treatment of cryptosporidiosis. The project aims to refine a new class of CDPK1 inhibitors and define optimal tissue targeting strategies to efficiently treat cryptosporidiosis, which is caused by the Cryptosporidium parasite...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to develop a vaccine against cryptosporidiosis, a common cause of diarrheal disease in sub-Saharan Africa and Asia. The $242,250 award to the University of Virginia will fund research to optimize the systemic and cellular immune responses of prototype vaccines targeting specific Cryptosporidium parasite antigens, and...
The U.S. National Institute of Allergy and Infectious Diseases (NIAID) awarded a $147,656 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania. The grant, awarded on November 24, 2024, will fund research to uncover the three-dimensional ultrastructure, molecular architecture, and composition of the Cryptosporidium host-parasite interface....
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $269,054 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to the University of California, Merced to investigate host-parasite interactions and susceptibility mechanisms to low virulence Toxoplasma gondii strains. The project aims to leverage the Collaborative Cross mouse panel and parasite genetics to identify novel host genes and pathways that determine disease outcomes following primary T. gondii...
The National Institute of Food and Agriculture (NIFA) within the U.S. Department of Agriculture awarded a $790,000 Project Grant to the University of Illinois under the Agriculture and Food Research Initiative (AFRI) competitive grants program (CFDA 10.310). The four-year project aims to develop novel drug therapies to treat Cryptosporidium parvum infections in livestock. C. parvum is a parasite that causes serious diarrheal illness in calves, lambs, and goat kids worldwide. Currently, there are...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is providing $205,125 to the Hennepin Healthcare Research Institute (HHRI) to investigate Plasmodium vaccination in an improved mouse model that mimics human immune responses. The goal is to define the immune response to Plasmodium vaccination and test an IL-15 adjuvant to boost vaccine-induced immunity. The research will...
This Project Grant award of $2,366,783.00 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will fund research to determine the molecular processes by which infectious spores of the fungus Cryptococcus transition into vegetatively growing yeast (germinate) and how this process influences disease. The overarching goal is to gain a better understanding of the fundamental biology of pathogenic fungi,...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $147,656 to The Children's Hospital Corporation (doing business as Boston Children's Hospital) to conduct research on the role of transmembrane proteins for Plasmodium cell division. The research aims to decipher the precise location of transmembrane proteins within the Plasmodium basal complex, a critical structure...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $515,875 to the University of Florida to conduct research on the mechanisms underlying Cryptococcus neoformans-induced meningoencephalitis and neurotoxicity in a CD4 T cell-deficient mouse model. The goal is to elucidate how the Cryptococcus polysaccharide capsule component glucuronoxylomannan (GXM) affects basal...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a 5-year, $832,071 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to Seattle Children's Hospital to develop a universal transmission blocking vaccine (TBV) against multiple Plasmodium species that cause malaria. The project aims to characterize broadly neutralizing monoclonal antibodies (mAbs) and human naturally acquired immunity against mosquito stage antigens HAP2 and HAP2P, which can block...