This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will provide $195,607 to Dr. Danielle Alfano at the Washington University in St. Louis to conduct research on the role of the ADAM10 protein in sepsis pathogenesis. The key objectives are to: 1) understand how diverse pathogens activate ADAM10 in the endothelium, 2) characterize ADAM10 substrates released during systemic infection, and 3) examine how an ADAM10 genetic variant may increase risk of lethal sepsis. This 5-year award will support Dr. Alfano's career development through targeted training in vascular biology, host-pathogen interactions, and proteomics, enabling her to become an independent, R01-funded researcher focused on identifying pathogen-specific molecular determinants and risk factors for severe sepsis.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $195.6k | 7/31/24 |