Project Grant R01AI184460
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $109,476 to the University of Wisconsin-Madison under the Allergy and Infectious Diseases Research program (CFDA 93.855) on November 30, 2025, with a completion date of May 31, 2027. This Project Grant supports fundamental research to understand the molecular mechanisms governing drug efflux in bacterial multidrug resistance transporters, specifically the NorA pump. The research...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Wisconsin–Madison a $427,625 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective August 1, 2025, through July 31, 2027. The award supports research and development activities focused on creating an innovative probiotic-based therapeutic delivery system. The project centers on developing plasmid-independent, carbohydrate-regulated...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Wisconsin-Madison a $414,305 Project Grant on February 9, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct basic biomedical research characterizing PACE (Proteobacterial Antiseptic Efflux) transporter proteins. The research will employ a multipronged approach to determine the substrate specificity, transport mechanisms, and structural...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded University of Wisconsin–Madison a Project Grant of $427,625 on February 2, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct biomedical research on bacterial pathogenesis. The project, titled "Defining the Role of YeiH in Salmonella Pathogenesis," will run through January 31, 2028. The research focuses on understanding how the YeiH protein...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $233,250 to the University of Wisconsin–Madison on June 9, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support research investigating peptidoglycan modification mechanisms that activate NOD2 pattern recognition in Neisseria gonorrhoeae infections. The research addresses a critical clinical problem: during pelvic inflammatory disease caused by...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Wisconsin–Madison a Project Grant of $753,899 on February 2, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the mechanisms by which butyrate affects Clostridioides difficile (CD) fitness and pathogenesis. The research addresses a critical public health need, as CD infections cause approximately 450,000 infections, 15,000 deaths,...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Wisconsin-Madison a $615,446 Project Grant on April 3, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support a five-year research initiative concluding March 31, 2031. The award funds basic biomedical research investigating novel mechanisms of arterivirus entry, cellular infection, immune evasion, and persistence in mammalian hosts....
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded University of Wisconsin–Madison a $791,200 Project Grant (CFDA 93.855: Allergy and Infectious Diseases Research) effective July 1, 2026, through June 30, 2031, to develop optimized pharmaceutical inhibitors targeting Naegleria fowleri, a parasitic amoeba responsible for primary amebic meningoencephalitis with a mortality rate exceeding 97 percent. The research team will design and synthesize...
- Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Wisconsin–Madison a $1.12 million Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) on July 25, 2025, with a completion date of June 30, 2030. This research initiative investigates the FSA3 prophage family as a molecular regulatory switch controlling beta-toxin (β-toxin) production in Staphylococcus aureus, a leading causative agent of...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Wisconsin - Madison a $427,625 Project Grant effective February 1, 2026, through January 31, 2028, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award funds research into the mechanisms of fallopian tube tissue damage caused by Neisseria gonorrhoeae infection and associated pelvic inflammatory disease (PID). The research will utilize human...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Wisconsin–Madison a Project Grant totaling $1,591,093 under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective July 1, 2026, through June 30, 2030. This research grant funds a four-year investigation into the role of cyclic di-adenosine monophosphate (c-di-AMP) in bacterial pathogenesis, specifically examining how this nucleotide second messenger regulates virulence in Listeria monocytogenes (LM), an important intracellular pathogen model. The research will elucidate mechanisms by which c-di-AMP accumulation attenuates bacterial virulence through impairment of cell wall biogenesis and inhibition of virulence program activation, with the ultimate objective of informing development of novel antibiotics or antibiotic adjuvants targeting c-di-AMP hydrolysis. The deliverables include fundamental research findings addressing two primary mechanisms: (1) characterization of how c-di-AMP regulates peptidoglycan homeostasis and identification of c-di-AMP-binding proteins involved in cell wall synthesis, and (2) elucidation of mechanisms by which c-di-AMP inhibits glutathione metabolism and virulence activation in LM. The project leverages genetic platform mutants and suppressor analysis to identify molecular targets and advance understanding of bacterial virulence regulation, thereby supporting broader therapeutic development efforts within infectious disease research.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.6m | 7/1/26 |