This Project Grant award for $862,440.00 was made by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports the development and evaluation of a new humanized mouse model to study gene editing therapies targeting chronic hepatitis B virus (HBV) infection. The key objectives are to: 1) Evaluate the anti-HBV efficacy of HBV gene therapy in liver-humanized NSG-PIZ mice, including assessing...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $835,137 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to the Icahn School of Medicine at Mount Sinai. The goal of this 5-year project is to develop a repository of 50 monoclonal antibodies (25 anti-hamster and 25 anti-guinea pig) that can be used to study immune and inflammatory responses in hamster and guinea pig animal models, which are important for researching infectious...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $360,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Virginia Polytechnic Institute & State University (Virginia Tech) to develop a gerbil model to delineate the mechanism of Hepatitis E Virus (HEV) extrahepatic pathogenesis. The key objectives are to: 1) Determine the effect of HEV-3-induced pyroptosis in neurovascular unit (NVU) cells and identify the mechanisms of...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $598,764 to The Trustees of Princeton University to conduct research aimed at disrupting the formation of HBV cccDNA to combat chronic HBV infection, particularly in the context of HIV co-infection. The key objectives are to: 1) determine whether genetic disruption of host factors involved in HBV cccDNA...
This $510,306 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to advance the understanding of virus-host interactions for developing a cure against chronic hepatitis B virus (HBV) infections. The primary goal is to investigate the mechanisms by which interferon-alpha treatment can lead to a functional cure for HBV, as well as explore the impact of HBV...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $883,119 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Scripps Research Institute to develop a novel mRNA vaccine and immunotherapy against hepatitis B virus (HBV) infection. The award supports research to investigate viral and cellular factors that hinder effective antigen expression and improve vaccine antigens to elicit potent antibody and T cell responses to cure HBV...
This $814,790 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to uncover the immune mechanisms underlying hepatitis B virus (HBV) surface antigen clearance, which can lead to a clinical cure for chronic HBV infection. The principal investigators at the University of California, San Francisco (UCSF) will leverage mouse models and clinical samples from HBV patients to conduct a...
The University of Southern California received a $621,698 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research) to conduct research on mother-to-child transmission of hepatitis B virus (HBV). The goal is to understand how HBV and its antigens in the mother affect the anti-HBV immunity of her children, which can lead to chronic HBV infection. The research will identify maternal HBV factors that promote HBV...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded Emory University a $673,158 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop a proteomics atlas of HIV/HBV co-infections for advancing HBV cure strategies. The project aims to use robust co-culture systems, CRISPR screens, and multi-omics approaches in primary human hepatocytes and CD4+ T cells to discover and validate host factors and antivirals against HIV/HBV...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to develop a simplified and cost-effective mouse model of Mycobacterium abscessus lung disease. The $426,938 award to The Johns Hopkins University will fund research to verify the reproducibility of a new mouse model using additional M. abscessus isolates and evaluate the model's ability to replicate the efficacy...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $756,589 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to Utah State University to develop a Syrian hamster model for Hepatitis B Virus (HBV) infection. The project aims to: 1) Establish a humanized-NTCP hamster model susceptible to HBV infection; 2) Characterize acute and chronic HBV infection pathogenesis and immune responses in the hamster model; and 3) Test antiviral drugs, immunoregulators, and epigenetic modifiers for suppressing chronic HBV infection in the hamster model. This novel HBV-susceptible hamster model is expected to facilitate the development of new HBV therapeutic approaches and a functional cure. The project will run from August 2024 to July 2029. Utah State University has also subcontracted a portion of the work to the University of Pittsburgh, which will receive $205,779 to support the development of the HBV hamster model.