Project Grant R01AI179614
- Federal Grant Award Summary Virginia Polytechnic Institute & State University (Virginia Tech) received a $452,769 Project Grant award on August 11, 2025, from the National Institute of Allergy and Infectious Diseases under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on the impact of BDGR-49 treatment on Venezuelan Equine Encephalitis Virus (VEEV)-induced neurological sequelae. The research project, to be completed by July 31, 2027, addresses a...
- Federal Grant Award Summary Virginia Polytechnic Institute & State University (Virginia Tech) received a $191,163 Project Grant from the National Institute of Allergy and Infectious Diseases under the Allergy and Infectious Diseases Research program (CFDA 93.855) awarded February 5, 2026, with completion scheduled for January 31, 2028. The grant supports research on the transmission dynamics and pathogenesis of contemporary Mayaro virus (MAYV) strains, addressing the emerging public health...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $883,119 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Scripps Research Institute to develop a novel mRNA vaccine and immunotherapy against hepatitis B virus (HBV) infection. The award supports research to investigate viral and cellular factors that hinder effective antigen expression and improve vaccine antigens to elicit potent antibody and T cell responses to cure HBV...
- Federal Project Grant Award Summary Virginia Polytechnic Institute & State University (Virginia Tech) received a $422,355 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded July 23, 2025, with completion targeted for June 30, 2027. The grant funds mechanistic and structural studies examining the signaling histidine kinase GacS from Pseudomonas aeruginosa, a nosocomial...
- Federal Grant Award Summary Virginia Polytechnic Institute & State University (Virginia Tech) received a $414,482 Project Grant award from the National Institute of Allergy and Infectious Diseases under the Allergy and Infectious Diseases Research program (CFDA 93.855) on July 24, 2025, with a completion date of June 30, 2027. The research focuses on developing an improved oncolytic virus therapeutic to treat glioblastoma, an aggressive brain cancer with poor prognosis. The project aims to...
- The federal Project Grant award of $249,000 from the National Institute of Allergy and Infectious Diseases (NIAID), CFDA 93.855 Allergy and Infectious Diseases Research Program, supports research on the host response to Hepatitis Delta Virus (HDV) infection. The primary objectives are to elucidate the mechanisms by which HDV pathogenesis occurs, with a focus on the role of the pattern recognition receptor MDA5 in recognizing HDV infection and the subsequent activation of antiviral genes. The...
- Federal Grant Award Summary Hbvtech, LLC received a $258,750 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded September 1, 2025, with a completion date of August 31, 2026. The funding supports the development of HBVZ10, a novel gene therapy candidate designed to obtain Investigational New Drug (IND) approval for chronic hepatitis B virus (HBV) treatment. HBVZ10 utilizes an...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to investigate the role of the Rift Valley Fever Virus (RVFV) non-structural small (NSS) protein in inhibiting the host autophagy pathway. The $128,052 award to Virginia Polytechnic Institute & State University will fund research to characterize the interaction between the NSS protein and the LC3 autophagy...
- The Baruch S. Blumberg Institute received a $195,750 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective February 10, 2026 through January 31, 2028. The award supports the development and validation of a novel hepatitis B virus (HBV) infection reporter system designed to enable unbiased genome-wide screening of host factors involved in HBV infection. This innovative system...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded the University of Vermont & State Agricultural College a $433,423 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective August 12, 2025, with completion targeted for July 31, 2027. This biomedical research project focuses on characterizing the endoplasmic reticulum (ER)-specific autophagy response, termed ER-phagy, as a regulatory mechanism...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $360,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Virginia Polytechnic Institute & State University (Virginia Tech) to develop a gerbil model to delineate the mechanism of Hepatitis E Virus (HEV) extrahepatic pathogenesis. The key objectives are to: 1) Determine the effect of HEV-3-induced pyroptosis in neurovascular unit (NVU) cells and identify the mechanisms of HEV-induced pyroptosis via the caspase 1-mediated canonical pathway, 2) Infect gerbils with different HEV genotypes (HEV-1, HEV-3, HEV-4) to delineate the mechanisms of HEV-induced neuroinflammation and neurological injuries, and 3) Identify if treatment with a caspase 1 inhibitor can reduce neuroinflammation and lesions in the central nervous system of HEV-infected gerbils. This research aims to elucidate the underlying mechanisms of HEV-associated extrahepatic pathogenesis, particularly neurological sequelae, to inform potential therapeutic targets.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $360.0k | 11/9/23 |