Project Grant R01AI183400
Award Date
7/8/24
Completion Date
6/30/29
Dollars Obligated
$854K
Federal Agency
National Institute of Allergy and Infectious Diseases
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Boston, MA 02118, USA
Similar Awards
This $502,861 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will support research to investigate the role of the human protein PCIF1 in regulating interactions between the HIV virus and host cells. The key objectives are to: 1) Define the dynamics and mapping of human RNA methylome modifications induced by HIV infection and methamphetamine exposure; 2) Determine how HIV alters...
The federal Project Grant award R01AI187175, issued by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $765,274 to Boston Medical Center Corporation for a research project titled "Defective HIV Proviruses and Persistent Innate Immune Activation". The project aims to investigate the role of defective HIV proviruses in perpetuating chronic inflammation in HIV-infected CD4+ T cells and...
This federal Project Grant award, totaling $794,045.00, was issued by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant aims to study the host cellular drivers of class II cytokine-mediated viral control across different stages of HIV infection, from acute infection to antiretroviral therapy (ART) interruption. The key products and services to be delivered under this grant include: 1) implementing...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $211,950 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to the University of California, Irvine to investigate the role of nucleic acid-containing immune complexes in driving immune activation and endothelial dysfunction in people living with HIV who are on antiretroviral therapy. The key research objectives are to: 1) Measure the inflammatory response to these nucleic acid-containing immune...
This federal Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support research focused on understanding the epigenetic regulation of the HIV-1 viral RNA cap and its linkage to HIV's ability to modulate host immune signaling. The total funding amount is $696,828.00 and the award date is August 14, 2024, with an ultimate completion date of June 30, 2029. The research...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a 5-year, $500,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to conduct research aimed at modulating T cell activation to combat HIV persistence. The key objectives of the research project are to: Identify and perturb regulatory mechanisms governing antigen-refractory HIV-specific CD8+ T...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $815,573 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Leland Stanford Junior University (Stanford University) to study HIV-induced inflammation in perinatally-infected adolescents on long-term antiretroviral therapy (ART). The goal is to identify the inflammatory networks and viral factors driving persistent inflammation during chronic, treated HIV infection in this...
This $197,366 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to advance the scientific understanding of how the human immune system naturally restricts a specific subset of HIV, known as X4-tropic virus. The grant recipient, The Washington University, will conduct research to: 1) characterize the molecular mechanisms driving the immune system's restriction of...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $220,224 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Chicago. This grant supports computational investigations into the assembly, maturation, and uncoating processes of the HIV-1 virus. The research aims to enhance the mechanistic understanding of how viral RNA is packaged, which could aid in the design of future therapeutics targeting viral assembly and...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $1,010,290.00 to Emory University to investigate the role of alveolar macrophages as potential HIV reservoirs and their contribution to persistent inflammation and immune activation in people living with HIV (PLWH) on antiretroviral therapy (ART). The key objectives are to: 1) Determine the extent of HIV proviral...