This federal Project Grant award of $586,250 from the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 Allergy and Infectious Diseases Research program supports research to investigate how distinct age-associated B cell subsets can protect the aged from influenza. The project aims to determine the potential of different age-associated B cell subsets to respond to influenza infection and generate antibody-secreting cells, B cell memory, and long-lived...
This $693,465 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support research by Cornell University to construct a molecular atlas of T cell development in lymph nodes and determine how cellular interactions and communication networks change during CD8+ T cell priming throughout childhood. The research aims to provide a new paradigm for understanding T cell activation and...
This Project Grant award, valued at $1,500,314 and awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), is focused on engineering a hydrogel-based human immune organoid to generate antigen-specific germinal center (GC) B cells and enable forced affinity maturation ex vivo. The goal is to examine the in vivo engraftment of the engineered human B cells delivered via injectable gels. This innovative...
This $806,693 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research) supports research at New York University School of Medicine to elucidate the mechanisms governing lymphangiogenesis (growth of lymphatic vessels) in acute and homeostatic inflammation, and determine the functional consequences of lymphatic encapsulation of B cell follicles on germinal center dynamics. The research aims to resolve the...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to develop a hydrogel-based "aged" immune organoid system to study the epigenetics and differentiation of aged B cells. With total funding of $2,980,142 over the award period from July 2024 to May 2029, the project seeks to: Engineer a tissue-engineered model of aged lymphoid tissues that can recapitulate the...
This Project Grant award of $130,368 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to define how B cell receptor (BCR) binding site copy number is developmentally regulated to optimize antigen recognition and enable affinity-driven antibody selection within B cell germinal centers. The project aims to construct a BCR binding site counter tool to measure the absolute number of...
This federal Project Grant award for $633,074 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Sloan-Kettering Institute for Cancer Research. The grant supports research to define the mechanisms by which the placenta protects itself from harmful B cell and antibody responses, while preserving the ability to mount effective immune responses to foreign antigens during pregnancy. Key...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $153,512 to Emory University to investigate the role of intrahepatic plasma cells in clearing hepatitis C virus (HCV) infection. The goal is to characterize the mechanistic origins of liver-resident plasma cells that arise during acute hepaciviral infection, with the aim of informing strategies for an effective...
This federal Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to develop a new tool for measuring functional B cell immunity against influenza infection. The $811,009 award, effective November 13, 2024 through October 31, 2029, aims to: 1) enhance and optimize a microfluidic device to capture and separate peripheral B cells based on their B cell receptor...
This federal Project Grant award of $820,623.00 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research) supports research to investigate the genetic determinants of SPI1 expression and activity in human germinal center B cells. The research, led by The Children's Hospital of Philadelphia Research Institute, aims to establish the role of SPI1, a master transcriptional regulator, in human health and disease by: Identifying non-coding...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $778,829 over 5 years to Emory University to conduct research on early life B-cell and plasma cell development in the human spleen. The key objectives are to: 1) characterize B-cell development and cytokine/metabolic regulators in early life versus adulthood; 2) examine the phenotype and functions of mature B-cell subsets and their spontaneous differentiation into antibody-secreting plasma cells in the fetal spleen; and 3) analyze the antigen specificity and effector functions of the natural antibody repertoire that emerges in the fetal spleen. This research aims to establish the human spleen as a unique reservoir for the development and survival of public B cells, plasma cells, and natural antibodies that provide protection against common pathogens, commensals, and self-antigens, especially in early life.