This federal Project Grant award, valued at $499,746 and awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to uncover the genetic basis and molecular mechanisms underlying T cell propensity towards autoimmunity. The award supports research to 1) elucidate the role of mitochondrial cristae morphology regulation in effector T cell functions, 2) understand the relationship between mitochondrial cristae integrity and effector T cell responses, and 3) determine the impact of mitochondrial cristae integrity on T cell-mediated autoimmunity using animal models. This innovative study leverages a unique genetic tool, the TMEM11 knockout mouse system, to investigate the physiological role of cristae morphology and integrity in effector T cells. The research outcomes are expected to advance the understanding of the connections between mitochondrial oxidative stress, epigenetic regulation, and T cell function in the context of autoimmune diseases.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $499.7k | 11/8/24 |