Project Grant R01AI179729
Award Date
11/18/24
Completion Date
10/31/29
Dollars Obligated
$640K
Federal Agency
National Institute of Allergy and Infectious Diseases
Awardee
Duke University (TP7EK8DZV6N5)
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Durham, NC 27710, USA
Similar Awards
This $705,557 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award will fund research at Emory University to investigate the role of monocytes and T cells in promoting viral control and clearance of SARS-CoV-2 in the upper and lower respiratory tract. Specifically, the research aims to determine the contribution of monocytes in supporting protective T cell responses,...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $640,735.00 to Emory University to conduct research on understanding the mechanisms of CD8+ tissue-resident memory T cells (TRM) that mediate protection against respiratory virus transmission. The research aims to investigate the characteristics, durability, and molecular mechanisms of respiratory tract TRM...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $153,512 to Emory University to investigate the role of intrahepatic plasma cells in clearing hepatitis C virus (HCV) infection. The goal is to characterize the mechanistic origins of liver-resident plasma cells that arise during acute hepaciviral infection, with the aim of informing strategies for an effective...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) totaling $831,755 supports research to investigate the role of lung-resident macrophage subsets, particularly nerve- and airway-associated macrophages (NAMs), in regulating type 2 immune responses and tissue homeostasis. The research aims to elucidate the mechanisms by which these macrophage populations mediate protective...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will provide $1,934,958.00 to The University of Texas Southwestern Medical Center to conduct research on the mechanisms by which respiratory viruses, including SARS-CoV-2 and RSV, use cilia on nasal epithelial cells to gain entry into the respiratory system. The research aims to gain a better understanding of the critical...
This $380,320 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to elucidate the dynamics of human CD8 T cell responses to SARS-CoV-2 and investigate how CD8 T cell homeostasis may be altered in Long COVID. The research aims to define the differentiation lineages of SARS-CoV-2-specific CD8 T cells, understand how epigenetic features influence their functional...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $147,656 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to St. Jude Children's Research Hospital Inc. The grant supports research to determine: 1) the specificity underlying mucin-mediated autolysis inhibition in Streptococcus pneumoniae; 2) the impact of mucin-mediated autolysis inhibition on pneumococcal cytotoxicity; and 3) the genetic determinants required for prolonged...
This federal Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to develop a new tool for measuring functional B cell immunity against influenza infection. The $811,009 award, effective November 13, 2024 through October 31, 2029, aims to: 1) enhance and optimize a microfluidic device to capture and separate peripheral B cells based on their B cell receptor...
The University of Rochester received a $722,958 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award supports research to investigate how a novel monocyte-derived cell subset produces galectin-1, which activates CD8 T cells and enhances their tissue-residency and anti-viral memory responses in the respiratory tract. The research aims to determine the mechanisms by which...
This $318,085 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant aims to better understand the role of antibodies, antigens, and cellular immunity in controlling viral infections through Fc-dependent mechanisms like antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and complement-dependent cytolysis (CDC). The research...