The National Heart, Lung, and Blood Institute (NHLBI) awarded a $172,176 Project Grant to Albert Einstein College of Medicine to conduct a pilot study titled "Reducing Morbidity in Sickle Cell Disease-PREVENT Acute Chest Syndrome System (PACSYSTEM) Pilot Study." This 5-year grant, awarded on June 1, 2024, aims to improve health outcomes for children and youth with sickle cell disease by using implementation science methods to address barriers and enablers faced by healthcare...
This National Heart, Lung, and Blood Institute (NHLBI) Project Grant award under the Cardiovascular Diseases Research program (CFDA 93.837) provides $156,340.00 to the Connecticut Children's Medical Center to develop and test a communication-enhancement intervention for healthcare providers (HCPs) to improve health outcomes in pediatric sickle cell disease (SCD). The 5-year grant will fund research activities including literature reviews, qualitative research with adolescent SCD patients and...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research Federal Grant Program (CFDA 93.837), will fund a research study to investigate sex and gender influences on inflammation and pain in sickle cell disease. The award, valued at $496,503, will be administered by The Trustees of the University of Pennsylvania (the Awardee) from September 1, 2024 to July 31, 2028. The study has two main objectives: 1) to ascertain sex- and...
This $677,777 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support a study examining the impact of HIV status, age, and chronic immune activation on responses to the pneumococcal conjugate vaccine (PCV20) among older adults living with and without HIV. The study will measure acute (30-day) and long-term (2-year) immune responses following PCV20 vaccination across four participant groups: 1) older adults living with HIV, 2) older HIV-uninfected...
This federal Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports a longitudinal cohort study to examine the impact of early childhood malaria prevention interventions on malaria risk in school-age children in Ghana. The study, titled "IMPACT OF EARLY CHILDHOOD MALARIA PREVENTION ON MALARIA RISK AT SCHOOL ENTRY (ERASE)", will evaluate the epidemiological and...
This $310,644 Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to identify factors influencing parental hesitancy towards seasonal respiratory vaccines (SRVs) for children in the post-COVID-19 pandemic era. The key objectives are to: 1) determine the determinants of parental SRV hesitancy, 2) identify pediatricians' perceived challenges and...
The National Institute of Nursing Research (NINR) awarded a $159,432 Project Grant (CFDA 93.361 - Nursing Research) to the University of Pittsburgh to assess communication needs, adapt the SBAR3 patient-provider communication intervention, and evaluate its feasibility and acceptability for improving assertive communication among adults with sickle cell disease (SCD) and their healthcare providers. The project aims to fill an evidence gap by understanding communication challenges in SCD care...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $637,526 to Duke University to conduct research on the role of sickle red blood cells (RBCs) in activating neutrophils and promoting vaso-occlusion in sickle cell disease (SCD). The key objectives of the research are to: 1) delineate the characteristics of sickle RBCs that contribute to neutrophil activation, 2) examine the...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $179,280 to The Trustees of the University of Pennsylvania to investigate how early-life nutritional stress impacts neutrophil development and function, and how this may contribute to the severity of sickle cell disease. The research aims to evaluate the correlation between diet, disease severity, and neutrophil activity in sickle...
This federal Project Grant award, provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), aims to adapt and preliminarily test an individualized care plan (ICP) prototype for inpatient sickle cell disease (SCD) vaso-occlusive episode (VOE) care. The total award amount is $191,792.00 over the project period of September 17, 2024 to August 31, 2029. The key objectives are to: 1) develop an ICP prototype adapted from the...