Project Grant R01AG104067
- The National Institute on Aging awarded a $7.287 million cooperative agreement to Arizona State University on September 1, 2026, under the Aging Research program (CFDA 93.866). The award funds a five-year research initiative running through August 31, 2031, examining heterogeneity in aging using a free-ranging rhesus macaque population on Cayo Santiago Island, Puerto Rico—the world's longest-running primate field station. The research program addresses three integrated questions: quantifying how...
- The National Institute on Aging awarded Arizona State University $655,917 under the Aging Research program (CFDA 93.866) on August 15, 2026, to develop and validate deep learning methods that enhance retinal color fundus photography image quality, automate retinal biomarker identification for Alzheimer's disease pathology, and enable scalable, cost-effective preclinical AD risk assessment. The project will create an unsupervised method using optimal transport-guided generative adversarial...
- The National Institute on Aging awarded the University of California Irvine $5,101,916 on July 1, 2026, under the Aging Research program (CFDA 93.866) to examine daily dynamics of social connection and their influence on physical and cognitive functioning across the adult lifespan. The research uses longitudinal daily diary datasets from the Midlife in the United States Study (MIDUS), including four waves of diary data across approximately 20 years (beginning in 2002, 2014, and 2023) and two...
- The National Institute on Aging awarded Arizona State University $484,575 on September 1, 2026, under the Aging Research program (CFDA 93.866) to evaluate the impact of dietary choline on cognitive decline and Alzheimer's disease biomarkers in rural populations, particularly in Arizona where AD incidence is elevated and elder adults in geographically isolated communities face significantly higher risks of cognitive decline yet remain drastically understudied. The project will investigate...
- The National Institute on Aging awarded Arizona State University $436,228 on June 1, 2026, under the Aging Research program (CFDA 93.866) to evaluate the impact of glucagon-like peptide-1 receptor agonists on sarcopenia in older adults. The research project will measure muscle mass and the mechanisms regulating muscle mass—including muscle protein synthesis and breakdown—using stable isotope tracer methodologies in older patients before and six months after GLP-1 RA treatment. The study will...
- The National Institute on Aging awarded Arizona State University $431,750 under the Aging Research program (CFDA 93.866) on September 1, 2026, to define the mechanisms underlying the protective effects of the RELN-COLBOS variant in Alzheimer's disease. The funded research leverages stem cell bioengineering, genome editing, and neurodegenerative disease modeling to elucidate the neuroprotective mechanisms of the RELN-COLBOS variant, a rare Reelin variant identified in a PSEN1 mutation carrier...
- The National Institute on Aging, a component of the Department of Health and Human Services National Institutes of Health, awarded $819,959 to The Regents of the University of California, San Francisco on September 3, 2026, under the Aging Research program (CFDA 93.866) to support research on end-of-life isolation among older adults. The project, titled "Dying Alone: Understanding and Addressing End-of-Life Isolation Among Older Adults," addresses the clinical and public health...
- The National Institute on Aging awarded Arizona State University $675,329 on May 1, 2026, under the Aging Research program (CFDA 93.866) to characterize cellular pathology and biomarkers in an Alzheimer's disease model developed through gene delivery in aged macaque monkeys. The research extends prior work conducted under a companion R24 grant in which the investigators developed a tauopathy model by injecting an adeno-associated virus carrying an aggregation-prone human tau variant...
- The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $3.356 million on September 2, 2026, under the Aging Research program (CFDA 93.866) to identify distinct multidimensional risk profiles for loneliness in stroke survivors during the first year after stroke. The research will examine how risk factors cluster across individual, interpersonal, and community levels to create distinct loneliness profiles among stroke and transient ischemic attack (TIA)...
- The National Institute on Aging awarded the University of Arizona $396,241 on September 1, 2026, under the Aging Research program (CFDA 93.866) to conduct a longitudinal, multi-modal study tracking neuroplasticity changes in preclinical and prodromal Alzheimer's disease stages using transcranial magnetic stimulation (TMS) integrated with blood and MRI biomarkers. The study employs TMS to assess non-invasive, repeatable neurophysiological measures of neuroplasticity and correlates these...
The National Institute on Aging awarded Arizona State University $1,249,351 on September 1, 2026, under the Aging Research program (CFDA 93.866) to examine day-to-day fluctuations in loneliness and their relationship to biological and functional aging outcomes across multiple timescales. The research will identify patterns of daily loneliness—average daily loneliness, loneliness volatility (day-to-day fluctuations), and loneliness reactivity to daily triggers—and map how these patterns predict long-term biological, physical, cognitive, and functional aging outcomes. The project will investigate whether unhealthy behaviors such as smoking, alcohol use, and poor sleep compound the effects of loneliness on accelerated aging. The work leverages two existing longitudinal studies: the Midlife in the United States Study (MIDUS, ages 35–80) and the Berlin Aging Study (BASE-II, ages 70–90), providing data spanning over a decade. Work is performed in Tempe, Arizona, with a period of performance through May 31, 2031. The assistance type is a Project Grant. Arizona Board of Regents serves as parent entity to Arizona State University's Office of Research and Sponsored Projects Administration (Orspa), which administers the award.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $106.2k | 8/19/26 | ||
| Not listed | $571.6k | 8/18/26 |