Project Grant R01AG102720
- The National Institute on Aging awarded Virginia Commonwealth University $552,883 on January 1, 2026, under the Aging Research program (CFDA 93.866) to conduct research on the selective vulnerability of cholinergic neurons in Alzheimer's disease. The award is a Project Grant with performance extending through November 30, 2030, at the Richmond, Virginia campus. The funded research investigates how soluble oligomeric amyloid-beta 42 (oAB42) drives selective degeneration of basal forebrain...
- The National Institute on Aging awarded the University of Southern California $149,190 on August 6, 2026, under the Aging Research program (CFDA 93.866) to investigate how early-stage Alzheimer's disease disrupts coordinated release dynamics between acetylcholine and norepinephrine in the cortex and how this discoordination impairs cognitive performance. The research characterizes the evolution of coordinated cortical acetylcholine and norepinephrine release activity in vivo in wildtype mice,...
- The National Institute on Aging awarded the University of Connecticut Health Center $459,322 on September 15, 2026, under the Aging Research program (CFDA 93.866) to investigate the molecular intersection of tau, phosphatases, and Alzheimer's disease. The research identifies how serine/threonine protein phosphatases (PPPs) bind tau and regulate tau phosphorylation status in health and disease. The project leverages nuclear magnetic resonance spectroscopy, cryo-electron microscopy, and...
- The National Institute on Aging awarded Yale University $638,941 under the Aging Research program (CFDA 93.866) on September 1, 2026, to conduct metabolic imaging of olfactory bulb dysfunction in Alzheimer's disease. The research will use longitudinal magnetic resonance imaging (structural MRI and functional MRI) and magnetic resonance spectroscopy to identify structural, functional, and metabolic alterations in the olfactory bulb across transgenic TGF344-AD rats and age-matched wild-type...
- The National Institute on Aging (NIA) awarded a $2,168,393 Project Grant (CFDA 93.866) to Yale University to examine the role of kynurenic acid in age-related cognitive deficits. The 3-year grant, starting September 1, 2023, will study how increased kynurenine inflammatory signaling with aging impairs higher cortical function in the dorsolateral prefrontal cortex (DLPFC) through blockade of NMDAR and α7-nAChR receptors, leading to working memory deficits. The research will test strategies to...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $198,352 to the University of Georgia Research Foundation, Inc. on March 15, 2026, under the Aging Research program (CFDA 93.866) to support research on molecular determinants of age-related cognitive decline in the basal forebrain to lateral entorhinal cortex circuit. The research identifies molecular signatures of vulnerability in the basal forebrain cholinergic neuron (BFCN) to lateral entorhinal...
- The National Institute on Aging awarded New York University $642,063 under the Aging Research program (CFDA 93.866) on January 15, 2026, to investigate gabaergic circuit targets for modulating entorhinal cortex and hippocampal dynamics in Alzheimer's disease. The research examines vasoactive intestinal peptide and cholecystokinin inhibitory neuron microcircuits within hippocampal area CA1, with the hypothesis that modulating activity in these circuits can improve lateral entorhinal cortex–CA1...
- The National Institute on Aging awarded the University of Virginia $583,815 on August 15, 2026, under the Aging Research program (CFDA 93.866) to support research into oligodendrocyte lineage dysfunction during aging and Alzheimer's disease. The project aims to understand how myelin loss—a pathology common to both aging and Alzheimer's disease—develops in the central nervous system and to identify therapeutic targets for cognitive impairment. The research focuses on oligodendrocyte precursor...
- The National Institute on Aging awarded the University of Rochester $656,829 under the Aging Research program (CFDA 93.866) on January 1, 2026, to investigate selective vulnerability of the fronto-insular network in aging and Alzheimer's disease through integrated structural, functional, and molecular analyses in mouse models. The research integrates in vivo two-photon imaging to track dendritic spine dynamics and dopaminergic terminal remodeling, fiber photometry to measure neural activity...
- The National Institute on Aging awarded Yale University $507,741 under the Aging Research program (CFDA 93.866) on August 1, 2026, to define the spatial relationship between early endosomal abnormalities, amyloid pathology, and early-stage tau hyperphosphorylation in primate models of sporadic Alzheimer's disease. The project addresses a gap in understanding the earliest molecular convergence points in Alzheimer's pathology. While soluble phosphorylated tau at threonine 217 (pT217tau) and...
The National Institute on Aging awarded $780,217 to the University of Connecticut Health Center on September 1, 2026, under the Aging Research program (CFDA 93.866) to conduct longitudinal imaging of prefrontal cholinergic dynamics and cognitive flexibility in an Alzheimer's disease model. The research combines chronic two-photon imaging, fluorescent acetylcholine reporting, in vivo beta-amyloid labeling, and cell-type-specific chemogenetic and optogenetic control to test whether amyloid-beta pathology degrades calcium dynamics and acetylcholine tone in prefrontal-cortex projection-defined subnetworks, and whether boosting cortical cholinergic interneuron activity restores network stability and cognitive flexibility through M1-muscarinic and alpha-7-nicotinic mechanisms. Aim 1 tracks calcium and acetylcholine signals monthly in corticothalamic, corticostriatal, and corticocortical pyramidal neurons of APP^NL-G-F and wild-type mice during a head-fixed two-armed bandit task, quantifying how activity loss and cholinergic hypo-response relate to plaque accrual. Aim 2 tests circuit rescue through chronic HM3DQ activation of cortical cholinergic interneurons from months 4–8, endpoint stereologic counts, dual-color calcium imaging in glutamatergic and GABAergic populations under sustained cortical cholinergic interneuron drive, and all-optical mapping of acute cortical cholinergic interneuron stimulation with M1 and alpha-7 agonist and antagonist applications. Performance occurs in Farmington, Connecticut, with a period of performance from September 1, 2026, through June 30, 2031. The award is classified as a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $780.2k | 8/28/26 |