Project Grant R01AG100278
- Federal Grant Award Summary Brown University received a $438,625 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) to conduct research investigating cellular quiescence and senescence phenotypes in aging and age-associated diseases. The award, effective June 1, 2026 through May 31, 2028, will deliver fundamental research examining the quiescence-senescence continuum hypothesis, which posits that cellular quiescence (reversible cell cycle...
- Federal Project Grant Award Summary Brown University received a $438,625 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded on August 15, 2025, with completion anticipated by July 31, 2027. The funded research project addresses the life cycle dynamics of senescent cells—cells that have permanently ceased dividing in response to molecular damage. The research will examine how the senescence phenotype evolves in both young and aged cells...
- Federal Project Grant Award Summary Brown University received a $150,114 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded March 3, 2026, with completion targeted for September 29, 2027. The grant supports research estimating the effects of Medicare Advantage (MA) enrollment on health outcomes and care quality among long-stay nursing home residents aged 65 and older. The project addresses a significant gap in understanding how MA...
- Federal Grant Award Summary This $1.42 million Project Grant, awarded September 30, 2025, by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), funds biomedical research at Weill Medical College of Cornell University through June 30, 2030. The award supports investigation into the mechanistic relationship between apolipoprotein E4 (ApoE4), cholesterol 25-hydroxylase (CH25H), and tau-induced neurodegeneration in Alzheimer's disease (AD). The research focuses...
- Federal Project Grant Award Summary The National Institute on Aging awarded Brown University a $770,702 Project Grant on September 20, 2025, under the Aging Research program (CFDA 93.866) to develop and deliver a research education program titled "Best Practices for the Measurement and Analysis of Cognitive Data in the International Health and Retirement Study (HRS) Family and Its Harmonized Cognitive Assessment Protocol (HCAP)." The grant addresses barriers to widespread utilization...
- Federal Grant Award Summary The National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), awarded J. David Gladstone Institutes a Project Grant of $1,602,386 (awarded February 15, 2026; completion January 31, 2031) to investigate how the APOE4 allele disrupts brain energy metabolism in Alzheimer's disease (AD). The research employs innovative assays and advanced imaging techniques to measure metabolic fluxes and characterize how APOE4 reprograms brain energy metabolism...
- Federal Grant Award Summary The National Institute on Aging awarded Columbia University's Health Sciences Division a $6.93 million Project Grant on August 1, 2025, under the Aging Research program (CFDA 93.866) to develop a multi-organ artificial intelligence-derived endophenotype (MAE) chart for personalized Alzheimer's disease and aging research. The four-year project, extending through July 31, 2029, will integrate large-scale multi-omics and multi-organ biomedical data with advanced...
- Federal Grant Award Summary The Johns Hopkins University received a $618,410 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded February 1, 2026, with a completion date of January 31, 2029. The award supports the development of a deep learning-based miniature microscope designed to enable early detection and characterization of Alzheimer's disease (AD) pathology in preclinical models. The research addresses critical limitations in existing...
- Federal Grant Award Summary Oregon Health & Science University (OHSU) received a $659,094 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective January 1, 2026 through December 31, 2030. This award supports the development of the first noninvasive retinal fluorescence imaging technology for early detection of Alzheimer's disease (AD). The project addresses a critical clinical need by creating an alternative to expensive,...
- Federal Grant Award Summary Brown University received a $438,625 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded April 1, 2026, with a completion date of March 31, 2028. The award supports research examining the long-term effects of Hurricane Katrina on the health, well-being, and mortality outcomes of older New Orleans residents aged 60 and above. The project leverages previously developed linked data sources to conduct medium-...
Brown University received a $636,372 Project Grant award from the National Institute on Aging (Aging Research program, CFDA 93.866) effective June 15, 2026, with completion targeted for February 28, 2031. The project delivers a multimodal optical imaging and artificial intelligence analytics platform designed to uncover the etiology of late-onset Alzheimer's disease (LOAD) in individuals carrying the apolipoprotein E4 (APOE4) allele and identify therapeutic intervention targets. The research addresses a critical knowledge gap regarding how APOE4 disrupts microvascular resilience—hypothesized to be the initial pathological event in LOAD, often preceding amyloid-beta and tau protein accumulation by years. The research team will develop an open-source imaging-plus-AI platform and conduct a longitudinal, rigorous study incorporating three primary research objectives: (1) optimization of high-throughput optical coherence tomography angiography (OCTA) for awake mice to map vascular topology and flow heterogeneity while tracking amyloid-beta/tau progression and behavioral outcomes over a 12-48 week period; (2) fusion of two-photon calcium imaging with OCTA risk mapping to identify mechanisms by which APOE4 impairs endothelial calcium waves and connexin-43 gap junction communication; and (3) testing of vascular-targeted therapeutics—including statins, PCSK9 inhibition, and SIRT1 activation—alone and in combination with anti-amyloid agents. These research deliverables directly support the National Institute on Aging's mission to identify prevention and treatment strategies for Alzheimer's disease and related dementias.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $636.4k | 6/9/26 |