Project Grant R01AG098482
- This Project Grant award, provided by the National Institute on Aging under CFDA Program 93.866 - Aging Research, supports a $2,516,316 research initiative led by Harvard Medical School to investigate neuronal activity-responsive DNA repair mechanisms and their contribution to cognitive aging and Alzheimer's disease. The key products and services to be delivered under this 3-year grant include: Mapping the landscape of activity-induced DNA double-strand breaks (DSBs) in wild-type mice and...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,851,569.00 in funding to The Washington University to conduct research on how early brain development informs later neurodegeneration, with a focus on Alzheimer's disease. The project aims to determine if regions of the brain with high plasticity during early development are more susceptible to pathological changes later in life, and if adverse developmental conditions have...
- This $427,625 Project Grant was awarded by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866). The grant was awarded to The Washington University in St. Louis to support research evaluating novel transcription factors that regulate astrocyte identity, reactivity, and their roles in the pathogenesis of Alzheimer's disease (AD) and Parkinson's disease (PD). The research aims to systematically evaluate 10 candidate transcription factors identified...
- The National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), has awarded a $2,631,670 project grant to The Washington University to investigate age-related deficits in episodic memory for the content and structure of naturalistic events. The 4-year project, starting September 1, 2025, aims to refine the understanding of the process of episodic memory loss in aging and Alzheimer's disease and its links to brain pathology. The study will assess how aging...
- The federal Project Grant award for "MULTISCALE MODELING AND EMPIRICAL STUDIES OF NORMAL AND PATHOLOGICAL BRAIN AGING" was provided by the National Institute on Aging under the Aging Research program (CFDA 93.866). The $636,342 award will support research at Boston University Medical Campus from August 1, 2025 to April 30, 2030. The project aims to investigate the relationship between myelin dystrophy, synapse loss, and neuronal hyperexcitability in the aging brain, and how these...
- The National Institute on Aging (NIA) awarded The Leland Stanford Junior University (Stanford University) a $428,563 Project Grant under the Aging Research Program (CFDA 93.866) to develop a modular cell-on-chip platform to study how neuronal activity regulates myelin sheath formation and how these dynamics are altered in neurodegenerative disease. The 2-year project will enable fine-tuning of neuronal stimulation, recording of extracellular activity, and high-resolution imaging of myelin...
- The National Institute on Aging (NIA), part of the U.S. Department of Health and Human Services, awarded a $132,472 Project Grant under the Aging Research program (CFDA 93.866) to the University of Massachusetts Medical School (UMMS). The grant, with a performance period from September 4, 2025 to May 31, 2027, will support research to understand the regulation of apoptotic sensitivity (programmed cell death) in the brain during normal aging and in Alzheimer's disease and other...
- The University of Massachusetts Medical School (UMass Medical) was awarded a $1,507,500 Project Grant from the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to conduct a study on spatial single-cell analysis of somatic mutations in the human brain during aging and neurodegeneration. The goal is to develop and apply new single-cell whole-genome sequencing methods to study somatic mutations in neurons from late-stage Alzheimer's disease and...
- This $3,101,237 Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Pittsburgh supports research investigating the beneficial immune response triggered by persistent DNA damage in aging. The project aims to elucidate the mechanism linking persistent DNA damage to the expression of the NLRP12 gene, which has been shown to improve the function of hematopoietic stem and progenitor cells in mouse and human models of DNA repair deficiency and...
- This $427,625 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to elucidate the mechanisms by which microgliopathy, a genetic neurological disorder, causes early-onset dementia. The research will investigate how the loss of the DAP12 protein in microglia, the immune cells of the brain, leads to heightened signaling of the RUNX and STAT3 pathways. This dysregulation is hypothesized to disrupt normal microglial functions and induce brain pathology and...
This National Institute on Aging (NIA) Project Grant award of $593,146 to The Washington University in St. Louis, Missouri supports research to define new mechanisms that promote neuronal DNA repair and transcriptional fidelity across lifespan. The overarching goal is to better understand the cellular and molecular basis of brain aging and age-dependent cognitive decline, with a focus on how neurons balance transcription and DNA repair in the context of neuronal activity and aging. This research aims to provide insights into the links between activity-dependent transcription, DNA damage, and neurodegeneration, with implications for cognitive aging and neurodegenerative diseases. The award, with a period of performance from January 1, 2026 to November 30, 2030, is funded under the NIA's Aging Research program (CFDA 93.866).
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $593.1k | 12/24/25 |