Project Grant R01AG096920
- This Project Grant award of $3,304,237 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support a 40-year longitudinal study examining the links between early life adversity, cumulative life stress, and cellular aging in midlife women and their offspring. The study aims to assess which aspects of life course stress, including childhood, midlife, and cumulative stress, are associated with accelerated cellular aging at age 50. The study will repeat assessments of cell aging...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to identify which aspects of daily stress processes - frequency, severity, and affective reactions - are linked with heightened inflammatory biomarkers in older adults, and the extent to which these associations vary between men and women. The award of $148,500 will be used by the primary awardee, South Dakota State University, to conduct this research using data from the Einstein Aging Study. The...
- The University of Pittsburgh was awarded a $794,978 Project Grant from the National Institute on Aging (CFDA 93.866 - Aging Research) to conduct research on the mechanisms by which socioeconomic disadvantage across the lifespan impacts cognitive function and decline in midlife. The research will longitudinally examine accelerated epigenetic aging as a biological mechanism connecting individual and community-level socioeconomic disadvantage to poorer cognitive function and greater cognitive...
- This $2,991,725 Project Grant award, provided by the National Institute on Aging (CFDA 93.866 Aging Research), supports research into the role of reactive oxygen species as modulators of lifespan and age-related diseases. The 4-year project, which commenced on September 1, 2025, aims to investigate a novel longevity paradigm in C. elegans that is triggered by early-life oxidative stress and mediated by changes in the epigenetic landscape. The research will examine the conserved mechanisms...
- This $200,310 project grant from the Department of Health and Human Services' National Institutes of Health National Institute on Aging will fund research into the differential impact of adverse childhood experiences and aging on brain health. Specifically, the Oklahoma State University grant will pursue two aims: 1) characterize cognitive performance across emerging and older adult cohorts stratified by ACEs, and 2) characterize brain-derived neurotrophic factor levels across the two age...
- This federal Project Grant award of $240,069 from the National Institute on Aging (CFDA 93.866 - Aging Research) to Vanderbilt University will be used to explore the effects of lifestyle on immune system activity and molecular markers of aging across populations with diverse lifestyles, from traditional subsistence-level to highly urban. The research will focus on analyzing three age-associated molecular phenotypes - gene expression, DNA methylation, and telomere length - in peripheral blood...
- This Project Grant award, valued at $647,866.00 and provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), supports research to investigate the epigenetic regulation of nuclear cGAS activity and its role in aging-related inflammation. The key objective is to understand how aging-related changes in histone acetylation patterns and associated chromatin-binding proteins, such as BRD4, activate the innate immune sensor cGAS and contribute to chronic...
- This Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) is supporting the development of a "Multimodal, Multiscale and Multistage Systems Biology (M3SB) Infrastructure for Precision Medicine in Alzheimer's Disease and Longevity". The $802,034 award aims to conduct multi-modal analyses of genetics, multi-omics data, cross-species protein interactome networks, and human brain-specific functional genomic data to identify...
- The National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), awarded a $320,511 project grant to TRU Diagnostics Inc. to develop a novel diagnostic tool for chronic diseases. The project aims to create a "non-stochastic W function epigenomic roadmap" using systems-based dynamic modeling to capture the shifting homeostatic set points of epigenetic markers over time. This transformative approach aims to enable personalized, dynamic health forecasts...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $699,344 to Albert Einstein College of Medicine to investigate the impact of surgical stress on age-related changes and resilience, with a focus on sex differences. The project aims to quantify the spatial, temporal, and sex-dependent effects of surgical stress on aging hallmarks and determine how resilience may modulate these relationships. The 2-year award period runs from September 1, 2025 to...
This $1,391,989 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) will fund a study titled "Comprehensive Biological Data in NCHAT Bio: Chronic Stress, Inflammation, and Epigenetic Aging" at The Ohio State University. The study aims to assess biological markers of inflammation (interleukin-6, C-reactive protein) and epigenetic aging in a nationally representative sample of heterosexual and sexual minority coupled adults. This project will leverage the longitudinal National Couples' Health and Time Study (NCHAT) to fill critical empirical gaps on the links between stress, inflammation, and accelerated aging in the sexual minority population. Findings from this innovative health research could help identify social determinants and underlying mechanisms driving health disparities, which is a high scientific priority.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.4m | 8/29/25 |