Project Grant R01AG096902
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $433,125 will fund a study to investigate the relationship between microglia, neurons, and tau pathology in Alzheimer's disease. The research will utilize a novel model system of microglial co-cultures with hippocampal assembloids derived from patient-derived induced pluripotent stem cell (iPSC) lines with MAPT mutations and healthy controls. The goal is to explore how bidirectional changes...
- This $146,922 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to investigate physiological pathways that modulate the regulation of the tau protein, which is associated with neurodegenerative diseases like Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS). The research is being conducted by the Johns Hopkins University and aims to better understand how disruptions in the signaling pathway involving the enzyme GDE2 lead to...
- The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $804,450 Project Grant to the J. David Gladstone Institutes in San Francisco, CA. This grant, awarded on June 1, 2025, will fund a research project titled "Targeting NELL2 and GABAergic Dysfunction to Mitigate APOE4-Driven Pathogenesis in Alzheimer's Disease." The project aims to investigate the role of the APOE4 gene and its interaction with sex and aging in contributing to...
- This $5,274,018 project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The J. David Gladstone Institutes will study the susceptibility and resistance to the detrimental effects of the Apolipoprotein E4 (APOE4) genetic risk factor for Alzheimer's disease. The research aims to characterize neurophysiological, behavioral, and neuropathological differences between new APOE4 mouse lines...
- This $816,661 Project Grant award, issued on June 1, 2025 by the National Institute on Aging (CFDA 93.866 Aging Research program), supports comprehensive research aimed at elucidating the molecular mechanisms underlying tauopathies such as Alzheimer's disease and frontotemporal dementia. The project, titled "Aberrant Proteomes in Tauopathy: Revealing Functional Consequences via Multimodal Proteomics", combines expertise in mass spectrometry-based proteomics and functional genomics to...
- This federal Project Grant award of $839,933 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to investigate the role of N6-methyladenosine (m6A) RNA modifications in microglial dysfunction and Alzheimer's disease (AD) pathogenesis. The project aims to systematically map m6A modification landscapes in microglia isolated from human brain tissue and human induced pluripotent stem cell-derived microglial models. The researchers will also use CRISPR-based...
- The National Institute on Aging (NIA) awarded a $442,357 Project Grant under the Aging Research program (CFDA 93.866) to the Research Foundation of the City University of New York (RFCUNY) on December 15, 2024. The grant aims to elucidate the molecular mechanisms that give rise to functionally neurodegenerative microglia, the brain's primary innate immune cells, which have been implicated as major determinants of Alzheimer's disease (AD) risk. The research will leverage novel mouse models and...
- This $1,592,854 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research at the University of Illinois to investigate the role of tau protein misfolding and hyperphosphorylation in Alzheimer's disease and related dementias. The central hypothesis is that pathogenic forms of tau represent a disruption of tau's normal scaffolding and signaling functions, leading to dysregulation of key kinases like CK2 and JNK. The research aims to define how...
- The National Institute on Aging (NIA), through its Aging Research Federal Grant Program (CFDA 93.866), awarded a $498,709 project grant to Epoch Biotech, LLC on August 20, 2025. The funding supports preclinical research on an ApoE-targeted antibody for treating Alzheimer's disease (AD). The project aims to modulate the interaction between apolipoprotein E (ApoE) and glycosaminoglycans (GAGs) using a therapeutic humanized antibody. The research builds on the discovery of a protective ApoE3...
- This $145,992 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the mechanisms underlying the trans-synaptic spreading of pathological tau in the human brain, and the role of amyloid-beta in modulating this process. The research aims to 1) characterize the molecular mechanisms of bivalent tau oligomer binding to healthy human synapses, as a function of amyloid-beta oligomers, and 2) evaluate how the presence or absence of...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to investigate how the cholesterol 25-hydroxylase (CH25H) enzyme and apolipoprotein E4 (E4) contribute to microglial inflammation and tau toxicities in Alzheimer's disease (AD). The total funding amount is $711,898, with an award date of September 30, 2025 and an ultimate completion date of June 30, 2030. The primary awardee is Weill Medical College of Cornell University, a leading academic medical institution. The research aims to characterize how the 25-hydroxycholesterol product of CH25H regulates cGAS-STING signaling in microglia, and how this pathway interacts with the AD genetic risk factor E4 to promote tau-mediated neurodegeneration. The findings could elucidate new therapeutic targets for mitigating neuroinflammation and tau pathologies in AD.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $711.9k | 9/15/25 |