Project Grant R01AG094747
- The National Institute on Aging awarded Wake Forest University Health Sciences $3.157 million on June 1, 2026, under the Aging Research program (CFDA 93.866) to conduct a four-year study examining the effect of caloric restriction on aging biomarkers, frailty, and multimorbidity in older adults with obesity. The funded research will measure whether short-term caloric restriction randomization affects a consensus-derived blood-based biomarker index comprising interleukin-6, TNF receptor 1, growth...
- The National Institute on Aging awarded The Administrators of Tulane Educational Fund (Tulane University) $871,998 on August 1, 2026, under the Aging Research program (CFDA 93.866) to investigate accelerated aging in the central nervous system of SIV-infected macaques. The research focuses on astrocyte dysfunction as a central mechanism driving HIV-associated accelerated aging and cognitive decline. The study examines how activated astrocytes in brain regions increase leukocyte transmigration...
- The National Institute on Aging awarded Tulane University four hundred twenty thousand seven hundred fifty dollars on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the role of L1 retrotransposons in normal brain aging and Alzheimer's disease in vivo. The research tests whether chronic L1 retrotransposon expression contributes to Alzheimer's disease progression using mouse models of L1 retrotransposition and Alzheimer's disease. L1 is a repetitive genetic...
- The National Institute on Aging awarded Weill Medical College of Cornell University $218,728 on March 3, 2026, under the Aging Research program (CFDA 93.866) to investigate vulnerable cell populations in aging-induced circadian clock remodeling and disruption. The recipient will conduct high-throughput single-nucleus RNA sequencing of flash-frozen tissues from young and aged mice sampled every four hours over two days in constant darkness. In the first aim, the investigator will profile seven...
- The National Institute on Aging awarded Wake Forest University Health Sciences $417,545 on June 1, 2026, under the Aging Research program (CFDA 93.866) to conduct a pooled analysis of the legacy effects of caloric restriction and exercise on bone strength in older adults. The project analyzes long-term follow-up quantitative computed tomography (QCT) scans and finite element modeling assessments acquired from 272 participants in the Health Outcomes After Participating in Exercise (HOPE) study,...
- The National Institute on Aging awarded Albany Medical College $246,000 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate inter-organelle dynamics during aging in eukaryotic cells. The work will characterize spatial contexts of inter-organelle communication using C. elegans as a model system to identify organellar signatures that develop during aging and proteostasis decline, establishing a platform to understand how aging impacts organelle interactions and...
- The National Institute on Aging awarded the University of New Orleans $149,000 on May 1, 2026, under the Aging Research program (CFDA 93.866) to investigate mechanistic links between elevated reproductive activity and reduced lifespan in Caenorhabditis elegans. The research addresses a gap in understanding how increased reproduction influences somatic aging by studying mated worms with hyperactive germlines. The investigator recently identified hedgehog signaling in mated worms as the first...
- The National Institute on Aging awarded $660,000 to The General Hospital Corporation (doing business as Massachusetts General Hospital) on August 15, 2026, under the Aging Research program (CFDA 93.866) to develop machine learning models for single-cell aging clocks that track aging trajectories across multiple organs and species. The recipient will integrate large-scale, publicly available single-cell transcriptomics datasets from mouse, rat, human, and invertebrate aging models totaling...
- The National Institute on Aging awarded Duke University $470,881 on August 15, 2026, under the Aging Research program (CFDA 93.866) to investigate reductive tricarboxylic acid (TCA) cycle metabolism in muscle stem cell aging. The research examines glutamine metabolism pathways in muscle stem cells and how age-related dysfunction in these pathways impairs tissue regeneration. The project uses stable isotope-enabled metabolic flux analysis to characterize both oxidative and reductive glutamine...
- The National Institute on Aging awarded $648,930 to the Regents of the University of California, doing business as University of California, Berkeley, on August 15, 2026, under the Aging Research program (CFDA 93.866) to develop human stem cell-based microphysiological systems for aging research. The recipient will create a novel human aging-on-a-chip platform integrating fat and liver tissues derived from human induced pluripotent stem cells (hiPSCs) and microfluidics using serum from young...
The National Institute on Aging awarded $616,284 to The Administrators Of Tulane Educational Fund, doing business as Tulane University, under the Aging Research program (CFDA 93.866) on August 1, 2026, to investigate long-term changes in blood proteomic whole-body and organ-specific biological aging clocks in response to calorie restriction interventions. The research builds on two long-term calorie restriction intervention studies—the POUNDS LOST trial and the CENTRAL trial—and will identify blood proteomic whole-body and organ-specific aging clocks and analyze their dynamic changes in response to calorie restriction (Aim 1). The recipient will examine relations of baseline levels and dynamic changes (up to 2 years during interventions and 10-year post-intervention follow-up) of blood proteomic whole-body and organ-specific aging clocks with changes in cardiometabolic outcomes (Aim 2). Additionally, the recipient will examine relations of dynamic changes in blood proteomic whole-body and organ-specific aging clocks with calorie restriction-induced metabolic adaptation and assess mediation effects of metabolic adaptation in the relations between proteomic aging clocks and cardiometabolic changes (Aim 3). The study will also examine relations of blood proteomic whole-body and organ-specific aging clocks with epigenetic aging clocks and multi-clock interactions. Work is performed in New Orleans, Louisiana. The period of performance runs from August 1, 2026 through July 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $58.8k | 7/29/26 | ||
| Not listed | $557.5k | 7/20/26 |