Project Grant R01AG094704
- Federal Project Grant Award Summary The University of Michigan's Regents received a $2,991,725 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective September 1, 2025, through August 31, 2029. This award supports fundamental biomedical research investigating how reactive oxygen species (ROS) and early-in-life oxidative stress modulate lifespan and aging processes. The research employs a multipronged approach utilizing model...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the University of Michigan $1,402,051 on August 1, 2025, under the Aging Research program (CFDA 93.866) to develop advanced machine learning methodologies for identifying factors associated with cognitive resilience in Alzheimer's disease and related dementias. The project, extending through April 30, 2030, involves the development of novel multimodal variational autoencoder (VAE) models designed to analyze...
- Federal Project Grant Summary The University of Michigan, through its Office of Research and Sponsored Projects, received a $655,198 project grant from the National Institute on Aging (Aging Research program, CFDA 93.866) effective March 1, 2026, through November 30, 2030. This award supports research focused on developing non-invasive methods for modulating microglia gene expression through peripherally administered antibody conjugates. The project addresses a significant gap in current...
- Federal Project Grant Award Summary The University of Michigan's Regents received a $442,695 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded May 1, 2025, with completion targeted for January 31, 2027. This proof-of-concept research initiative aims to develop immunocytokines—monoclonal antibodies (MAbs) or bispecific antibodies (BAbsbs) fused to macrophage colony-stimulating factor (M-CSF)—to achieve selective, sustained, and localized...
- Federal Grant Award Summary The University of Michigan received a $10.4 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded on August 1, 2025, with completion scheduled for July 31, 2029. This research initiative represents the first study evaluating personalized brain stimulation as a treatment for Posterior Cortical Atrophy (PCA), a neurodegenerative condition most commonly caused by Alzheimer's disease. The primary deliverable...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the University of Michigan's Regents a $298,419 Project Grant effective February 1, 2026, through January 31, 2031, under the Aging Research program (CFDA 93.866). This award supports the development of novel machine learning and computational statistical methods designed to analyze immune system data and advance understanding of immunosenescence and aging-related diseases. The research addresses critical...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the University of Michigan a $303,449 project grant effective June 1, 2025, through May 31, 2027, under the Aging Research program (CFDA 93.866) to investigate the genomic impact of transposable elements (TEs) in Alzheimer's disease and related dementias (ADRD). The research will leverage large-scale genomic datasets and clinical information from major Alzheimer's disease cohorts to overcome analytical challenges...
- Federal Grant Award Summary The National Institute on Aging awarded the Regents of the University of Michigan a $107,097 Project Grant effective September 16, 2025, through June 30, 2027, under the Aging Research program (CFDA 93.866). This research project investigates the relationship between sleep disturbances and age-related memory loss by examining how sleep deprivation alters the activity and connectivity of somatostatin-expressing inhibitory interneurons in the hippocampus. The research...
- Federal Grant Award Summary The National Institute on Aging awarded the Regents of the University of Michigan a $156,000 Project Grant under the Aging Research program (CFDA 93.866) to conduct a structural neuroimaging study examining the relationship between mild behavioral impairment (MBI) and brain network changes in early-stage Alzheimer's disease and related dementias (ADRD). Awarded on August 5, 2025, with completion targeted for April 30, 2027, the project will deliver a network-level...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a $595,472 Project Grant to the University of Wisconsin–Madison, effective August 1, 2025, through May 31, 2030, under the Aging Research program (CFDA 93.866). This award supports biomedical research directed toward understanding the physiological and molecular mechanisms underlying calorie restriction (CR), prolonged fasting, and their effects on aging, healthspan, and age-related diseases. The primary research...
The University of Michigan's Regents, Office of Research and Sponsored Projects, received a $1.73 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) to conduct comprehensive research on genetic determinants of cognitive outcomes under caloric restriction. The award, obligated on March 1, 2026, with completion anticipated by January 31, 2031, supports the first systems genetics analysis using the Diversity Outbred mouse panel to identify genetic factors and mechanisms underlying cognitive resilience during adult-onset caloric restriction. The research addresses a critical gap in understanding why caloric restriction—a robust dietary intervention for extending lifespan—paradoxically increases memory impairment incidence in aging mice, with findings expected to inform human cognitive health interventions. The project delivers two primary research objectives: Aim 1 involves comprehensive cognitive assessment of male and female aging mice under caloric restriction to identify genetic and network-based modifiers of cognitive performance; Aim 2 translates candidate genes and resilience factors identified in mice to human cohorts through validation against the Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy trial data, normal aging cohorts, and Alzheimer's disease populations. The research is performed at the University of Michigan's Ann Arbor facility and leverages the institution's extensive research infrastructure and interdisciplinary expertise in aging, neuroscience, and systems genetics to advance understanding of preventive interventions for age-related cognitive decline.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.7m | 2/18/26 |