Project Grant R01AG093122
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a $770,000 Project Grant to The Leland Stanford Junior University on August 15, 2025, under the Aging Research program (CFDA 93.866) to conduct basic science research on postoperative delirium in geriatric populations. The project, titled "Targeting Aging-Related Delays in Cognitive Recovery After Anesthesia by Attenuating Oxidative Stress: Implications for Alzheimer's Disease," will investigate the mechanisms by...
- Federal Project Grant Award Summary New York University School of Medicine received a $705,726 Project Grant award from the National Institute on Aging (Aging Research program, CFDA 93.866) effective September 1, 2025, through August 31, 2028. This multi-center feasibility randomized clinical trial will evaluate the efficacy and implementation of Monitored Anesthesia Care with Soft-Tissue Infiltration using Local Anesthesia (MAC-STILA) as an alternative to general anesthesia for older adults...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Columbia University's Health Sciences Division a $529,744 Project Grant effective February 15, 2026, through January 31, 2031, under the Aging Research program (CFDA 93.866). The award funds research investigating the mechanisms driving Alzheimer's disease progression through the entorhinal cortex-hippocampal circuit. The primary deliverables include longitudinal scientific investigations utilizing two-photon in...
- Federal Grant Award Summary Awardee: Pascall Systems, Inc. Funding Agency: National Institute on Aging (NIA) Federal Grant Program: Aging Research (CFDA 93.866) Award Amount: $1,998,535 Award Date: September 20, 2025 Project Period: September 20, 2025 – May 31, 2027 Pascall Systems, Inc. is developing and commercializing the PASCALL M1 system, an intraoperative electroencephalogram (EEG)-guided precision anesthesia management platform designed to prevent postoperative delirium (POD) in elderly...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Massachusetts General Hospital $868,901 on March 1, 2026, under the Aging Research program (CFDA 93.866) to conduct the Sleep and Circadian Rhythm Biomarkers of Postoperative Neurocognitive Recovery (SLEEP-POD2) study through January 31, 2031. This multisite longitudinal research initiative will enroll 400 older non-cardiac surgery patients (age 65+) from Boston and Baltimore to investigate the relationship between...
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $715,801 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) effective June 1, 2025, through March 31, 2030, to conduct research investigating the impact of hypertension and aging on postoperative delirium. The project delivers scientific research services examining the causal mechanisms whereby chronic hypertension contributes to delirium following surgical...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The Trustees of Columbia University in the City of New York $6.9 million through the Aging Research program (CFDA 93.866) for a four-year project running from August 1, 2025, through July 31, 2029. The award funds research to develop a multi-organ chart of personalized susceptibility to Alzheimer's disease and aging using large-scale multi-omics, multi-organ biomedical data, and advanced artificial...
- This $2,356,117 federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will support research to improve the perioperative management of patients with Alzheimer's disease and related dementias. The primary objectives are to: (1) identify the extent to which surgical patients with these conditions are at increased risk for adverse postoperative outcomes, and (2) estimate the association between various perioperative interventions and the incidence...
- Federal Project Grant Award Summary Beth Israel Deaconess Medical Center, Inc. (BIDMC) received a $1.63M Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective June 15, 2025, with completion targeted for March 31, 2030. The award funds research to identify proteomic signatures associated with postoperative delirium and long-term cognitive decline in older cardiac surgical patients. Building on findings from the DEXACET trial, which...
- Federal Project Grant Award Summary Award Details: Vigorous Mind, Inc. received a Project Grant award of $499,981 from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective August 1, 2025, with a completion date of July 31, 2026. The project addresses delirium prevention in hospitalized elderly patients with dementia—a condition affecting over 2.6 million U.S. older adults annually and contributing to $164 billion in annual healthcare costs. Products and...
The National Institute on Aging (NIA) awarded Columbia University's Health Sciences Division a $577,122 Project Grant on February 15, 2026, under the Aging Research program (CFDA 93.866) to conduct a clinical research study examining electroencephalogram (EEG)-guided anesthesia protocols for reducing post-operative delirium (POD) in elderly surgical patients. The primary deliverable is a randomized controlled trial involving elderly patients undergoing general anesthesia, stratified by cognitive status (Alzheimer's disease, mild cognitive impairment, or no cognitive impairment) and randomized to receive either standard anesthesia care or EEG-guided protocols incorporating real-time analysis of frontal alpha wave activity. The study will assess whether maintaining alpha waves during surgery through optimized medication administration reduces POD incidence and improves early neurocognitive recovery in this vulnerable population. The research addresses a significant clinical problem, as approximately 65% of elderly surgical patients experience POD, which increases hospital readmissions and mortality rates. The project, scheduled for completion on January 31, 2031, will generate evidence-based insights into the relationship between intraoperative brainwave activity and post-operative cognitive outcomes, with specific investigation of dexmedetomidine's effects on alpha wave preservation and POD prevention. Study results will inform anesthetic practice standards and contribute to NIA's mission of supporting biomedical research directed toward greater understanding of age-related diseases and the needs of older adults.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $577.1k | 2/3/26 |