Project Grant R01AG092953
- This $2,365,042 Project Grant was awarded by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866) to conduct research on the biological underpinnings of Alzheimer's disease and related dementias (ADRD). The research aims to better characterize the interplay between biological markers of neurodegeneration, vascular, nutritional, and inflammatory systems, and their interface with social and economic factors, by leveraging cross-national comparisons...
- This federal Project Grant award for $366,648.00 was provided by the National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), to New York University (NYU). The funding supports the development of statistical methods for improving estimation and prediction models related to Alzheimer's disease (AD) progression, leveraging data from longitudinal cohort studies. Specifically, the project aims to address challenges posed by complex truncation and censoring...
- This federal Project Grant award of $3,080,520.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to develop novel biomarkers for the early detection of Alzheimer's disease and related dementias (ADRD) using resting-state functional magnetic resonance imaging (rs-fMRI) data and machine learning. The research aims to address limitations of current ADRD biomarkers by leveraging the dynamics of functional connectivity networks and accounting for heterogeneity...
- This Project Grant award of $437,875 from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund a 2-year research project at the University of California, San Diego to quantify neurovascular protein lifetimes in the central nervous system under healthy, aging, and Alzheimer's disease conditions. The key objectives are to generate a comprehensive atlas of neurovascular protein lifetimes and identify changes associated with aging and Alzheimer's disease. The project will...
- This federal Project Grant award for $2,557,260 from the National Institute on Aging (CFDA 93.866 Aging Research program) will fund a study titled "Lifecourse Predictors and Mechanisms of Early Clinical ADRD among Black and White Adults in their Sixties". The study aims to investigate the transition from midlife to early late-life and identify the earliest manifestations of Alzheimer's disease (AD) and Alzheimer's disease-related disorders (ADRD) in a diverse population. The research...
- This federal Project Grant award of $839,933 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to investigate the role of N6-methyladenosine (m6A) RNA modifications in microglial dysfunction and Alzheimer's disease (AD) pathogenesis. The project aims to systematically map m6A modification landscapes in microglia isolated from human brain tissue and human induced pluripotent stem cell-derived microglial models. The researchers will also use CRISPR-based...
- This federal Project Grant award of $2,631,670 from the National Institute on Aging (CFDA 93.866 Aging Research) supports a research initiative at The Washington University to investigate age-related deficits in episodic memory. The project aims to determine how aging distinctly affects the content and structure of memory representations, and how this relates to dysfunction in different brain networks based on susceptibility to Alzheimer's disease pathology. The research will utilize plasma...
- The National Institute on Aging awarded a $4.6 million Project Grant to Cornell University under the Aging Research program (CFDA 93.866) to develop new imaging techniques for measuring microvascular blood flow in Alzheimer's disease and related dementia models. The award will support the design of an adaptive excitation source for 2-photon and 3-photon fluorescence microscopy to simultaneously measure blood flow speeds in approximately 300 cortical or 50 deep white matter microvessels. This...
- This $1,012,879 Project Grant was awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to New York University (NYU) to develop three novel statistical machine learning methods for Alzheimer's disease (AD) research using multi-view imaging, genomic, and clinical data. The specific aims include: 1) developing a multi-view data decomposition method to construct brain and genomic networks across AD statuses, 2) developing an optimal false discovery rate control method to...
- This federal Project Grant award of $3,188,901.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to better understand the relationships between in-vivo biomarkers for amyloid, tau, and neurodegeneration (ATN), neuropsychiatric symptoms, vascular risk factors, and genetic risks in Alzheimer's disease. The study will leverage data from large research cohorts like the Alzheimer's Disease Neuroimaging Initiative to develop and optimize machine learning models that can...
This federal Project Grant award, valued at $1,552,000.00 and provided by the National Institute on Aging (CFDA 93.866 - Aging Research), supports a research study examining the relationship between markers of vascular and immune dysfunction, such as platelet aggregation and neutrophil levels, and their association with dementia risk and increased Alzheimer's disease (AD) biomarkers. The study, conducted by New York University School of Medicine, aims to integrate biofluid biomarker data with advanced neuroimaging techniques to investigate the potential synergistic contributions of vascular dysfunction and neuroinflammation to AD progression. The research will be carried out over a period of approximately 5 years, with an expected completion date of May 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.6m | 9/5/25 |