Project Grant R01AG092798
- The National Institute on Aging awarded the University of Rochester $656,829 under the Aging Research program (CFDA 93.866) on January 1, 2026, to investigate selective vulnerability of the fronto-insular network in aging and Alzheimer's disease through integrated structural, functional, and molecular analyses in mouse models. The research integrates in vivo two-photon imaging to track dendritic spine dynamics and dopaminergic terminal remodeling, fiber photometry to measure neural activity...
- The National Institute on Aging awarded The Leland Stanford Junior University $423,500 on April 1, 2026, under the Aging Research program (CFDA 93.866) to investigate dynamic brain circuit mechanisms associated with apathy and disinhibition in individuals with Alzheimer's disease and related dementias. The project addresses neuropsychiatric symptoms that affect nearly 80 percent of individuals with dementia, particularly apathy and disinhibition linked to deficits in motivation and cognitive...
- The National Institute on Aging, a component of the Department of Health and Human Services, awarded $397,689 to the Research Foundation of The City University of New York (doing business as RFCUNY - Advanced Science Research Center) on September 1, 2026, under the Aging Research program (CFDA 93.866) for Project Grant R01AG103127. The award funds research into pathway-specific vulnerability of dopamine-glutamate neurons in aging and memory. The research examines how dopamine neurons...
- The National Institute on Aging awarded Marquette University $309,000 on May 15, 2026, under the Aging Research program (CFDA 93.866) to conduct longitudinal imaging studies in a preclinical Alzheimer's disease model aimed at identifying early biomarkers of cognitive decline. The project uses in vivo calcium imaging of prefrontal cortical neuronal ensembles and two-photon imaging of amyloid-beta deposits in a transgenic rat model to track changes in genetically defined excitatory and...
- The National Institute on Aging awarded $780,217 to the University of Connecticut Health Center on September 1, 2026, under the Aging Research program (CFDA 93.866) to conduct longitudinal imaging of prefrontal cholinergic dynamics and cognitive flexibility in an Alzheimer's disease model. The research combines chronic two-photon imaging, fluorescent acetylcholine reporting, in vivo beta-amyloid labeling, and cell-type-specific chemogenetic and optogenetic control to test whether amyloid-beta...
- The National Institute on Aging awarded the University of Virginia $583,815 on August 15, 2026, under the Aging Research program (CFDA 93.866) to support research into oligodendrocyte lineage dysfunction during aging and Alzheimer's disease. The project aims to understand how myelin loss—a pathology common to both aging and Alzheimer's disease—develops in the central nervous system and to identify therapeutic targets for cognitive impairment. The research focuses on oligodendrocyte precursor...
- The National Institute on Aging awarded Temple University $132,448 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate NMDAR/TRPM4 signaling and mitochondrial dysfunction in Alzheimer's disease. The project tests the functional coupling of N-methyl-D-aspartate receptors (NMDARs) and TRPM4 channels as a central mechanism of neurotoxicity in Alzheimer's disease and related dementias. Research employs induced pluripotent stem cell organoids carrying AD-causing...
- The National Institute on Aging awarded New York University $642,063 under the Aging Research program (CFDA 93.866) on January 15, 2026, to investigate gabaergic circuit targets for modulating entorhinal cortex and hippocampal dynamics in Alzheimer's disease. The research examines vasoactive intestinal peptide and cholecystokinin inhibitory neuron microcircuits within hippocampal area CA1, with the hypothesis that modulating activity in these circuits can improve lateral entorhinal cortex–CA1...
- The National Institute on Aging awarded the University of South Carolina $322,500 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the molecular and cellular mechanisms of cognitive decline in aging and Alzheimer's disease, with focus on D-serine metabolism and NMDAR signaling in the hippocampus. The research uses rodent models and human tissue samples to examine the roles of serine racemase and D-amino acid oxidase in hippocampal learning, memory, and NMDAR...
- The National Institute on Aging awarded Rutgers The State University of New Jersey $1,401,551 on December 15, 2025, under the Aging Research program (CFDA 93.866) to investigate the role of amyloid precursor protein (APP) metabolites in extracellular vesicle cargo and function in Alzheimer's disease. The recipient will conduct three research aims. The first aim investigates the molecular mechanism of APP-related cargo loading into extracellular vesicles (EVs). The second aim tests the effect...
The National Institute on Aging awarded RU School of Osteopathic Medicine $526,953 on August 15, 2026, under the Aging Research program (CFDA 93.866) to investigate neural circuits mediating motivation deficits in an Alzheimer's disease rat model. The recipient will characterize and manipulate ventral tegmental area and nucleus accumbens signaling in transgenic AD rats using optogenetics, in vivo electrophysiology, and fiber photometry to determine circuit-level mechanisms underlying deficits in anticipatory drive toward reward-predictive cues and loss of behavioral invigoration. The work addresses the correlation between apathy severity in Alzheimer's disease patients and nucleus accumbens deformation, with the goal of identifying therapeutic targets to rescue motivational function and potentially alleviate cognitive decline in AD patients with neuropsychiatric symptoms including apathy, anhedonia, and depression. Performance occurs in Stratford, New Jersey. The period of performance runs through May 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $527.0k | 8/14/26 |