Project Grant R01AG091162
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) in the amount of $2,433,859 supports research at The Johns Hopkins University to investigate age-related hearing loss and cognitive decline. The key objectives are to study the molecular, cellular, and connectivity changes in the central auditory system during normal aging and Alzheimer's disease, with the goal of developing targeted therapeutic strategies. The research integrates single-cell sequencing,...
- Federal Grant Award Summary Oregon Health & Science University received a $131,555 Project Grant award, effective July 1, 2025, through June 30, 2027, from the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173). This award supports research investigating how noise-induced hearing loss (NIHL) affects central auditory processing of complex, naturally occurring sounds at the cortical...
- Federal Grant Award Summary Oregon Health & Science University received a $780,000 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective June 15, 2025, through May 31, 2027. The award funds research investigating allelic expression imbalance in trisomy 21 (Down syndrome), with particular emphasis on understanding epigenetic mechanisms that regulate dosage-sensitive genes on chromosome 21. The research examines how epigenetic...
- Federal Project Grant Award Summary Oregon Health & Science University (OHSU) received a $108,512 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) on March 6, 2025, with a completion date of September 29, 2028. The award funds basic and translational research investigating the mechanisms by which endothelin-1 (ET-1) mediated ischemic vascular dysfunction contributes to Alzheimer's disease (AD) pathology and cognitive decline. The...
- This federal Project Grant award of $1,183,821.00 from the National Institute on Aging (CFDA 93.866 Aging Research) is supporting research to investigate the relationship between auditory test performance and the development of Alzheimer's disease pathophysiology, including amyloid-beta plaques and tau tangles. The research, led by Dartmouth College, will expand on previous findings that central (rather than peripheral) auditory test results correlate better with markers of Alzheimer's disease...
- Federal Project Grant Award Summary Oregon Health & Science University has been awarded $471,885 by the National Institute on Aging under the Aging Research program (CFDA 93.866) to conduct a two-year research project (Award Date: June 1, 2025; Completion Date: May 31, 2027) investigating the mechanisms by which hyaluronan protects brain vascular endothelial cells from ferroptosis. The research addresses vascular contributions to cognitive impairment and dementia (VCID), the second leading...
- Federal Grant Award Summary Oregon Health & Science University received a $659,094 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866) effective January 1, 2026, with a completion date of December 31, 2030. The grant funds development of the first fluorescence-based retinal imaging technology for early detection of Alzheimer's disease (AD). Leveraging the retina's role as a neurosensory extension of the brain, the research aims to create...
- This federal Project Grant award of $662,162.00 from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), will support research on binaural spectral and temporal integration with hearing loss and hearing devices. The key objectives of the research are to investigate abnormal binaural fusion and integration of spectral and temporal information in individuals with hearing loss who use...
- Federal Grant Award Summary The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded Tufts University School of Medicine a Project Grant totaling $779,636 on February 4, 2026, under the Research Related to Deafness and Communication Disorders program (CFDA 93.173). The award supports research through January 31, 2031, to characterize and develop therapeutic treatments for an accelerated aging model of the olfactory epithelium—the tissue responsible for smell...
- Project Grant Award Summary The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded The Medical University of South Carolina a Project Grant of $102,324 effective September 1, 2025, through August 31, 2027, under the Research Related to Deafness and Communication Disorders program (CFDA 93.173). This award supports research investigating macrophage and microglia dysfunction in age-related auditory nerve degeneration, with the objective of developing novel treatment...
Oregon Health & Science University (OHSU) received a $657,439 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective March 1, 2026, through January 31, 2031. The award funds research investigating synaptic and behavioral changes induced by hearing loss and Alzheimer's Disease (AD) in the auditory brainstem. The research will utilize mouse models with early-onset AD and hearing loss to examine how auditory signal propagation is affected across different stages of disease progression, with particular focus on neuronal excitability and synaptic strength changes within specialized synapses of the auditory brainstem, including the calyx of Held synapse and glycinergic and glutamatergic synapses. This research addresses a critical gap in understanding the intersection of hearing impairment and cognitive decline, as both conditions commonly co-occur in aging populations and compromise quality of life. By examining early-onset deficits in binaural hearing—the ability to process sound cues from both ears with temporal precision—the project aims to develop insights that could support early detection of Alzheimer's disease risk and inform interventions to mitigate the social isolation and cognitive decline associated with combined hearing and cognitive impairment.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $657.4k | 2/18/26 |