This Project Grant award of $550,627, funded by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866), supports research to investigate the role of oral microbially induced exosomes in the pathogenesis of Alzheimer's disease (AD). The primary objectives are to determine how exosomes released from gingival tissues during periodontal disease infection can cross the blood-brain barrier and induce senescence, neuroinflammation, and AD pathology. The...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $226,500 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Medical University of South Carolina. The grant, titled "CD38 Signaling in Aging-Associated Immune Responses Induced by Oral Pathogens," aims to define how oral pathogens affect aging-associated immune responses and determine if inhibition of the CD38 enzyme can alleviate inflammatory bone loss and...
This Cooperative Agreement award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $3,465,577.00 to examine the influences of socioeconomic stressors and education-related opportunities on oral health outcomes among a diverse cohort of emerging adults. The project aims to: 1) assess the impact of early adulthood socioeconomic factors on oral health over time, 2) examine how education-related...
This $2,356,117 federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will support research to improve the perioperative management of patients with Alzheimer's disease and related dementias. The primary objectives are to: (1) identify the extent to which surgical patients with these conditions are at increased risk for adverse postoperative outcomes, and (2) estimate the association between various perioperative interventions and the incidence...
This federal Project Grant award for $331,999 from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) aims to determine the causal relationship between poor oral health and heart disease. The primary awardee, Lehigh University, will construct polygenic scores using a GWAS-by-subtraction genomic structural equation model to identify genetic risk factors for poor oral health. They will then leverage this to...
This federal Project Grant award, provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), is aimed at quantifying the effects of poverty alleviation policies on the risk and disparities of Alzheimer's disease and related dementias (AD/ADRD). The $131,813 award, with a project period from May 1, 2025 to April 30, 2027, will enable the principal investigator at the Trustees of Boston University Medical Campus to: 1) integrate Medicare and Health and...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $442,750 to The Research Foundation For The State University Of New York (RF SUNY) to investigate the role of oral spirochetes in promoting neuroinflammation and dysfunction. The key objectives are to: 1) Characterize the ability of oral spirochetes to induce blood-brain barrier dysfunction, and 2) Assess the capacity of oral spirochetes to drive an inflammatory response in glial cells of the...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $852,049 to conduct a prospective observational cohort study to evaluate and predict improvement in oropharyngeal dysphagia (OD) among hospitalized patients with Alzheimer's disease and related dementias (AD/ADRD). The study aims to: 1) develop a machine learning model to predict which patients will have clinical OD improvement prior to hospital discharge, and 2) determine the association...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $2,803,617.00 in funding to Emory University to study the intersection of HIV-related periodontitis and antiretroviral therapy-induced immune reconstitution bone loss in people living with HIV. The research aims to investigate how these two conditions, which can both lead to alveolar bone and tooth loss, impact oral...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, provides $198,000 to The Pennsylvania State University (Penn State) to conduct research on the relationship between oral microbiome diversity and oral health disparities in the United States. The key objectives are to: 1) Analyze how oral microbiota diversity, composition, and abundance of individual species differ across...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) aims to elucidate the link between oral health and different subtypes of dementia, including Alzheimer's disease (AD) and vascular dementia (VAD). The total award amount is $1,530,868 and the project period runs from August 15, 2024 to April 30, 2029.
The key research objectives are to: 1) establish the relationship between poor oral health and clinical biomarkers of dementia, and the incidence of AD and VAD; 2) test biological pathways (systemic inflammation, accelerated aging, oral microbiome dysbiosis) linking oral health with AD and VAD; and 3) determine how social determinants of health (SDOH) moderate the relationship between oral health and dementia subtypes. The project will analyze multiple large population datasets to provide comprehensive insights. A sub-award of $263,002 was made to East Carolina University to assist with project administration, data analysis, and dissemination activities.