Project Grant R01AG089801
- This federal Project Grant award of $716,579, awarded by the National Institute on Aging (CFDA 93.866 - Aging Research), supports research to investigate the role of microglia, the immune cells of the brain, in the progression of Alzheimer's disease (AD). Specifically, the research aims to genetically dissect the relationships between different activated states of microglia and their involvement in complement-mediated synapse loss, which is a key neurobiological driver of cognitive decline in...
- This federal Project Grant award of $509,413.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to conduct research on the role of epitranscriptomic regulation of microglial cells in the development and progression of Alzheimer's disease (AD). The project will investigate how methylation of adenosine residues in mRNA (m6A modification) and its regulatory proteins are altered in the brains of AD patients, and how these changes impact microglial function and the brain's...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to gain a mechanistic understanding of the role of cellular senescence in the pathogenesis of Alzheimer's disease (AD). The $460,625 grant will fund research at the University of Massachusetts Medical School to dissect the separate P53/P21 and P16 senescence pathways and their functional consequences in AD using human induced pluripotent stem cell-based models. The 2-year project will produce...
- This $745,765 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the Icahn School of Medicine at Mount Sinai (ISMMS) in New York aims to investigate the effects of Alzheimer's disease (AD) risk genes and aging on human microglia activity and lipid metabolism. The key focus is on understanding how genetic variants associated with increased AD risk or longevity may impact microglia's ability to clear cholesterol/lipid-rich cellular debris, a critical...
- The University of Massachusetts Medical School (UMass Medical) was awarded a $1,507,500 Project Grant from the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to conduct a study on spatial single-cell analysis of somatic mutations in the human brain during aging and neurodegeneration. The goal is to develop and apply new single-cell whole-genome sequencing methods to study somatic mutations in neurons from late-stage Alzheimer's disease and...
- This federal Project Grant award for $831,583 was provided by the National Institute on Aging (CFDA 93.866 Aging Research) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to conduct research on "Characterizing Microvascular Impairment in Adults with Elevated Genetic Risk for Alzheimer's Disease." The project aims to elucidate the physiological mechanisms by which the APOE-E4 genetic risk factor contributes to microvascular impairment,...
- The National Institute on Aging (NIA), part of the U.S. Department of Health and Human Services, awarded a $132,472 Project Grant under the Aging Research program (CFDA 93.866) to the University of Massachusetts Medical School (UMMS). The grant, with a performance period from September 4, 2025 to May 31, 2027, will support research to understand the regulation of apoptotic sensitivity (programmed cell death) in the brain during normal aging and in Alzheimer's disease and other...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $804,450.00 to support research conducted by the J. David Gladstone Institutes in San Francisco, CA aimed at "Targeting NELL2 and GABAergic Dysfunction to Mitigate ApoE4-Driven Pathogenesis in Alzheimer's Disease." The research will investigate how the Alzheimer's disease risk factor ApoE4 interacts with sex and aging to contribute to neuronal network hyperactivity and cognitive...
- This Project Grant award for $466,125, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), supports research to analyze the effects of Alzheimer's disease on subcellular transcriptome dynamics and mitonuclear coordination in neuronal soma and projections. The research, conducted by Harvard Medical School, will use a novel technique called Subcellular Timelapse-Seq (STL-Seq) to simultaneously quantify the kinetic rates of transcription, nuclear export, ribosome...
- This $3,323,710 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research by the University of Massachusetts Medical School (UMMS) to investigate aberrant vesicular degradation and lipid metabolism in neurodegeneration. The key objectives are to: 1) interrogate the hypothesis that mutant profilin-1 (PFN1) impairs autophagy and vesicular degradation through interactions with phosphatidylinositol 3-phosphate and other phosphoinositides, using...
This Project Grant award of $445,130 from the National Institute on Aging (CFDA 93.866 Aging Research program) aims to elucidate the mechanisms by which MS4A genes regulate neurodegeneration in Alzheimer's disease and related disorders. The research is being conducted by the University of Massachusetts Medical School from January 1, 2026 to December 31, 2030. The project seeks to build on prior findings that genetic deletion of the MS4A6C gene significantly improves cognitive, behavioral, and cellular phenotypes across mouse models of neurodegenerative disorders including Alzheimer's, frontotemporal dementia, ALS, and multiple sclerosis. The research will examine the effects of deleting additional MS4A family members to further understand their role in regulating neurodegeneration and identify potential therapeutic strategies targeting MS4A genes for treating a range of neurodegenerative conditions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $445.1k | 12/23/25 |