Project Grant R01AG089703

Award Date 6/1/25
Completion Date 3/31/30
Dollars Obligated $529K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Atlanta, GA 30322, USA
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This $125,896 Project Grant, awarded by the National Institute on Aging under the Aging Research program (CFDA 93.866), supports a research project led by The Washington University in St. Louis. The project aims to utilize state-of-the-art single-nuclei multi-omic functional genomic analyses of healthy and Alzheimer's disease (AD) human brain tissue, as well as transgenic AD mouse models, to perform deep molecular characterization of AD risk and resilience pathways across genetic, epigenomic,...
This $766,467 Project Grant award was provided by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866) to the Georgia State University Research Foundation Inc. The funding supports the development of flexible multivariate models that can jointly analyze multi-scale neuroimaging and genomic data to better understand Alzheimer's disease and related dementias (ADRD). The proposed models aim to address key limitations of existing multivariate data fusion...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $784,596 to Northeastern University to conduct comprehensive and cell type-specific proteogenomic profiling of aberrant and mis-processed proteins in Alzheimer's disease (AD) and tauopathy models. The 5-year project aims to improve understanding of AD's causes, identify new therapeutic targets, and develop new tools for studying protein dysfunctions in AD. Key objectives include applying...
This federal Project Grant award of $125,373 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to identify genetic associations between Alzheimer's disease (AD) and cardio-cerebrovascular risk factors (CVRFs) such as hypertension and diabetes. The overarching goal is to elucidate the interplay between genes, CVRFs, and AD risk, with the potential to reveal novel molecular targets for prevention and treatment strategies tailored to diverse racial/ethnic...
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  1. Estimate genome-wide cis- and trans-acting quantitative trait loci (QTLs) for transcriptome-wide genes and proteome-wide proteins across multiple brain tissues.

  2. Leverage the QTL weights to improve the yield of separate tissue-specific transcriptome-wide association studies (TWAS) and proteome-wide association studies (PWAS) for AD dementia.

  3. Develop a novel analytical tool to conduct joint TWAS and PWAS, testing for genetic effects mediated by transcriptome, proteome, and their interactions.

  4. Validate the identified AD risk genes through computational and biological experimental approaches using a Drosophila model.

The research aims to advance understanding of the underlying molecular mechanisms linking genetic risk factors to AD/ADRD, with the goal of identifying new targets for drug discovery and therapies.

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