This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the Trustees of Indiana University, doing business as Indiana University Indianapolis, aims to discover novel tau proteoforms in blood that can differentiate Alzheimer's disease (AD) and progressive supranuclear palsy (PSP) from healthy volunteers. The $2,186,322 award, with a period of performance from August 15, 2024 to April 30, 2029, will leverage samples from completed tau immunotherapy clinical trials to overcome sensitivity limitations and identify tau biomarkers for early diagnosis of AD and non-AD tauopathies like PSP. The research seeks to characterize these novel tau proteoforms and make them available to enable further research on associating them with tau pathology, disease progression, and identifying patients for clinical trials.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $693.0k | 4/1/25 | ||
| Not listed | $746.7k | 8/8/24 | ||
| Not listed | $746.7k | 8/8/24 |