The National Institute on Aging (NIA) awarded a $871,043 Project Grant under the Aging Research (CFDA 93.866) federal grant program to the Northern California Institute For Research And Education, Inc. (NCIRE) to support the U.S. Deprescribing Research Network (USDEN). The funding will be used to: Grow and support a national, interprofessional community of researchers focused on deprescribing for older adults, with a particular focus on those with heightened vulnerability such as Alzheimer's...
This $243,000 Project Grant awarded by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) will fund a 5-year study focused on deprescribing potentially inappropriate medications (PIMs) for older adults with Alzheimer's disease and related dementias (ADRD) receiving home health care services. The key objectives are to: 1) Identify factors, barriers, and facilitators associated with routine PIM deprescribing for ADRD patients in home health care through a mixed...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Brown University will provide $2,238,104 from September 1, 2024 to August 31, 2027 to understand how prescribing cascades - where adverse events from one medication lead to the unnecessary prescription of another medication - arise and impact health outcomes among nursing home residents, especially those with Alzheimer's disease and related dementias. The research team will leverage nursing...
This federal Project Grant award of $676,912.00, funded by the National Institute on Aging's Aging Research program (CFDA 93.866), aims to examine the impact of medications on functional recovery and successful transition back to home for older adults discharged to a skilled nursing facility (SNF) after a heart failure hospitalization. The central hypothesis is that certain commonly prescribed medications may impair rehabilitation participation, interfere with functional recovery, and decrease...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $234,000.00 to the University of Colorado-Denver to develop and pilot a patient decision aid (DA) to support shared decision-making for pharmacologic treatments of dementia. The key products and services to be delivered include: Conducting a qualitative needs assessment on decision-making for dementia therapies among patients, caregivers, and clinicians. Simultaneously developing a patient DA...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $196,395.00 to the Regents of the University of Michigan to conduct research aimed at improving medication deprescribing decisions for patients with epilepsy across the lifespan. The key objectives are to: 1) Define how patient preferences influencing antiseizure medication decisions change over a patient's lifetime through surveys of ~300 patients; 2) Improve predictive models for...
This $679,475 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a national study examining antiepileptic medication use among patients with dementia residing in long-term care facilities. The study aims to: 1) characterize patient, provider, and facility factors associated with antiepileptic prescribing, 2) assess clinical outcomes of antiepileptic initiation compared to alternative medications, and 3) interview prescribers to understand...
This Project Grant award of $561,600 from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) supports a research project led by Dr. Matthew Growdon at the University of California, San Francisco (UCSF). The project aims to characterize medication use and management supports among people with dementia who live alone, understand their perspectives on medication use, and develop a stakeholder-informed framework to guide clinicians in optimizing medication use for...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Duke University is focused on investigating the impact of hypertension and aging on postoperative delirium. The $715,801 award, effective June 1, 2025 through March 31, 2030, aims to elucidate the specific contributions of endothelial cells and perivascular macrophages to surgery-induced neuroinflammation, blood-brain barrier disruption, and delirium-like behavior in aging and hypertension....
This $3,871,366 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to understand the neural mechanisms underlying attentional resilience in older adults. The primary objectives are to evaluate how processes related to attentional control, such as alpha power modulation and sensory processing enhancement, contribute to the ability to maintain attention and cognitive performance despite physiological stressors like inflammation or...