The National Institute on Aging (NIA) awarded a 3-year Project Grant (CFDA 93.866 - Aging Research) totaling $2,238,104 to Brown University to study prescribing cascades among nursing home residents with Alzheimer's disease and related dementias (ADRD). The research aims to identify risk factors for prescribing cascades, estimate their effects on medication usage, and quantify the impacts on adverse health outcomes like hospitalizations, falls, and mortality - especially for high-risk subgroups with severe cognitive impairment. The project will leverage a large database linking nursing home electronic health records, clinical assessments, and Medicare claims to apply novel causal inference methods. The findings are expected to provide clinically actionable evidence to guide prescribing, deprescribing, and medication management practices to minimize risks for nursing home residents with ADRD.
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