This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $508,525.00 to Mayo Clinic to investigate the role of adipose senescent cells in cognitive function and Alzheimer's disease progression. The project aims to determine the potential impacts of aging- or obesity-driven accumulation of adipose senescent cells on microglial senescence, cognitive decline, and Alzheimer's pathology using mouse models. The research will utilize Mayo Clinic's novel Adipoq-Ink-ATTAC mouse model to enable targeted depletion of senescent cells from adipose tissue. This work is intended to ascertain whether peripheral senescent cells represent potential therapeutic targets for neurodegenerative disorders, particularly Alzheimer's disease, to aid in the development of future intervention strategies.
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