Project Grant R01AG086134
- The National Institute on Aging (NIA) awarded a $785,348 project grant (CFDA 93.866 - Aging Research) to The Salk Institute for Biological Studies in La Jolla, California. The project, titled "Chronic Sleep Disruption is a Stressor for Healthspan and Lifespan", will investigate the biological mechanisms by which chronic sleep disruption (CSD) may interact with the aging process to increase the risk of age-related diseases. The research aims to determine if long-term CSD affects the...
- This federal Project Grant award of $125,000.00, provided by the National Institute on Aging (CFDA 93.866 Aging Research), supports research to investigate the relationship between sleep loss and neurodegeneration. The grantee, The Washington University, will use the funding to examine how sleep deprivation can epigenetically alter microglial responses to tau protein aggregates, which is a key pathological feature of Alzheimer's disease and other tauopathies. The research aims to identify...
- This federal Project Grant award of $101,915 from the National Institute on Aging (CFDA 93.866 - Aging Research) is funding research to investigate the impacts of pharmacological slow wave sleep enhancement on cognition and memory in an Alzheimer's disease (AD) mouse model. The study, led by researchers at Columbia University, will use two drug compounds, gaboxadol and trazadone, to assess whether enhancing slow wave activity can normalize sleep-wake disturbances, reduce amyloid plaque burden,...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to equip the candidate with skills to establish an independent research program focused on identifying modifiable lifestyle factors, such as physical activity and sleep, that can enhance cognitive resilience in aging and Alzheimer's disease-related dementias (ADRDs). The $129,659 award, with a project period from June 15, 2025 to March 31, 2030, will support a longitudinal study to assess whether...
- The National Institute on Aging (NIA) awarded Brigham & Women's Hospital Inc. a $2,576,936 Project Grant under the Aging Research federal grant program (CFDA 93.866) to characterize the variability in sleep spindle activity across a population and evaluate the use of sleep spindle dynamics as biomarkers for Alzheimer's disease, mild cognitive impairment, and trisomy 21. The 3-year project will develop statistical models and methods to analyze sleep spindle patterns and their relationship...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $684,924 to Northwestern University to conduct research on the relationship between the noradrenergic (NA) system, sleep quality, and cognitive function in older adults with insomnia. The project aims to systematically characterize central and peripheral measures of the NA system and assess their association with sleep quality and cognitive performance in older adults with insomnia, as well as...
- This federal Project Grant award of $442,938, provided by the National Institute on Aging (CFDA 93.866 Aging Research), supports research at the University of California, San Francisco (UCSF) to investigate the relationship between sleep, memory, and aging. The key objectives are to: 1) characterize how aging affects sleep patterns required for memory consolidation and synaptic plasticity during long-term memory formation; and 2) determine how upregulating the unfolded protein response can...
- The National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), awarded a $245,434 project grant to Wake Forest University Health Sciences (WFUHS) to examine the associations between early and later-life stress on later-life cognition and plasma biomarkers of Alzheimer's disease and related dementias (ADRD). The study aims to investigate how stress experienced across the lifespan, as well as perceived psychological stress, may impact cognitive decline and...
- The National Institute on Aging (NIA) awarded a $780,466 Project Grant (CFDA 93.866 Aging Research) to The Regents of the University of Colorado, doing business as the University of Colorado-Denver, with a period of performance from December 15, 2024 to November 30, 2029. The goal of this project is to develop digital biomarkers using single-channel sleep electroencephalography (EEG) to monitor brain health and detect pathological aging and early neurodegenerative changes, such as those seen...
- This Project Grant award, funded by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), provides $420,750 to Washington State University to investigate the complex interactions between aging, transcriptional processing, protein aggregation, sleep disturbance, and cognitive decline in an Alzheimer's disease rat model. The researchers will leverage innovative techniques, such as the use of single-chain variable fragments to evaluate protein oligomerization,...
This $612,005 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to characterize sleep slow-wave activity (SWA) and its relationship to chronic stress, accelerated aging, and Alzheimer's disease in a cohort of 200 Black older adults aged 55-80 in the United States. The award will support ambulatory overnight sleep monitoring, biomarker assessments, and cognitive testing to examine how chronic stress impacts SWA and its association with markers of Alzheimer's pathology. A subsample of 50 participants will be followed for up to two years to further determine the directionality of the relationship between SWA and Alzheimer's biomarkers. This project will provide an early-stage investigator the opportunity to apply their expertise in sleep SWA analysis to the domain of aging research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $612.0k | 9/8/25 |