This Project Grant award for $2,398,590.00, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to investigate the role of brain microcirculation and capillary endothelial cell energetics in the development of vascular cognitive impairment and dementia (VCID) observed in Alzheimer's disease (AD) and AD-related dementias. The...
This $300,000 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research by the University of South Florida to identify enhancer RNAs (eRNAs) and enhancer-centric gene regulatory networks involved in the development of vascular dementia. Specifically, the researchers will use genome-wide approaches like RNA-seq and ChIP-seq to map active enhancers and their associated eRNAs in the mouse hippocampus during the progression of vascular dementia...
This $1,120,805 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders federal grant program (CFDA 93.853), will support research to investigate how prior SARS-CoV-2 infection may increase the risk of vascular contributions to cognitive impairment and dementia (VCID). The research aims to: Determine how prior SARS-CoV-2 infection influences blood-brain barrier...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $794,341 to the University of Illinois to conduct research on the role of pathogen-induced cellular senescence and blood-brain barrier dysfunction in the development and progression of Alzheimer's disease. The 5-year project aims to leverage experimental mouse models, molecular characterization of endogenous retroviruses, and human induced pluripotent stem cell models to investigate...
This Project Grant award of $4,361,625 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a "VCID Center Without Walls for Understanding and Leveraging Small Vessel Cerebrovascular Disease Mechanisms in ADRD" at Washington University. The project aims to leverage advanced multi-omics and transcriptomic technologies to investigate the complex mechanisms underlying cerebral small vessel disease (CSVD) and its vascular contributions to dementia (VCID). Key...
This Project Grant award for $380,060 from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) supports research by the Arizona Veterans Research And Education Foundation, a non-profit organization, to evaluate anti-Medin immunotherapy for addressing vascular aging and related dementias. The project aims to develop and test the efficacy of an anti-Medin vaccine (Aim 1) as well as anti-Medin monoclonal antibodies (Aim 2) in preventing or attenuating...
This Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $10,847,672 to the J. David Gladstone Institutes, a non-profit biomedical research organization, to investigate the vascular-immune mechanisms underlying cerebral amyloid angiopathy (CAA) and Alzheimer's disease pathology. The research aims to elucidate the key microglial mechanisms regulating the formation of vascular CAA versus parenchymal amyloid-beta plaques, define single-cell and...
The National Institute on Aging (NIA) awarded a $2,244,471 Project Grant under CFDA 93.866 (Aging Research) to Oregon Health & Science University (OHSU) to develop a first-in-class, CNS-penetrant small molecule agonist for G protein-coupled receptor 39 (GPR39) as a potential treatment for vascular cognitive impairment and dementia (VCID). The 3-year project from September 2023 to August 2026 will use in vitro and in vivo assays to identify lead compounds, determine their safety and...
The National Institute on Aging (NIA) awarded a $471,885 Project Grant (CFDA 93.866 - Aging Research) to Oregon Health & Science University (OHSU) from June 1, 2025 to May 31, 2027. The project aims to investigate the mechanisms underlying brain vascular endothelial cell (BVEC) disruption following vascular brain injury, which can contribute to vascular cognitive impairment and dementia (VCID). Specifically, the project will test hypotheses related to how the glycosaminoglycan hyaluronan and...
This Project Grant award of $654,910 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to identify the molecular mechanisms underlying the contribution of cerebrovascular disease (CVD) pathologies to Alzheimer's disease and related dementias (AD/ADRD) in older adults. The award supports research at Rush University Medical Center to generate and analyze transcriptomic and proteomic data from white matter tissue samples, complementing existing data from gray matter. This...
This federal Project Grant award of $651,387 from the National Institute on Aging's Aging Research Program (CFDA 93.866) supports research into the role of varicella zoster virus (VZV) in increasing the risk of vascular dementia. The primary awardee, The Regents of the University of Colorado-Denver, will isolate plasma exosomes from individuals during and after acute zoster (shingles) episodes to analyze their content for proteins and miRNAs that may contribute to vascular dysfunction and accelerate vascular dementia risk. The project will also determine the mechanisms by which these non-infectious zoster exosomes promote cerebrovascular disease. This 5-year project aims to provide insights that could impact clinical practices around antiviral therapy duration and anti-platelet agent use for zoster, as well as increase support for vaccination to prevent shingles and reduce vascular dementia risk.
The University of Colorado-Denver has also awarded a $26,055 sub-grant to the Center for Clinical Studies LTD LLP to support a portion of the research activities.