This Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) to The Trustees of Columbia University in the City of New York provides $2,775,137 to conduct research on the role of aging-related factors in the transformation of pre-leukemic conditions to acute myeloid leukemia (AML). The key objectives are to 1) establish how transcriptional deregulation, inflammatory signals, and stromal niche interactions promote clonal outgrowth of pre-leukemic...
The federal Project Grant award of $146,922 from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), supports research to investigate the mechanisms underlying hematopoietic stem and progenitor cell (HSPC) dysfunction in myelodysplastic syndromes (MDS). The research focuses on understanding how environmental factors and age-related inflammation, mediated by the cGAS-STING pathway and neutrophil dysfunction, interact with the...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $105,952 to Weill Medical College of Cornell University to identify and characterize clonal expansions in aging and aging-related diseases. The key objectives are to: (1) develop tools to identify candidate somatic variants at scale from publicly available data, and (2) apply novel technologies that map genotype to epigenetic phenotype in single cells to analyze multiple tissues from...
This Project Grant award of $1,905,716.00 from the National Institute on Aging's Aging Research program (CFDA 93.866) will support research conducted by New York University School of Medicine to study the aging skeletal stem cell niche. The research aims to elucidate the molecular mechanisms regulating the inflammatory response in skeletal stem and progenitor cells (SSPCs) and the role of anti-inflammatory factors in resolving inflammation. By investigating how these pro- and anti-inflammatory...
This $344,111 federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports research at Loyola University of Chicago's Health Sciences Campus aimed at understanding and treating myelodysplastic syndromes (MDS), a group of bone marrow failure diseases. The research will investigate using inhibitors of the RIPK1 and TBK1 proteins to restore blood cell production, eliminate mutant hematopoietic stem/progenitor cells, and prevent MDS from...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $570,922.00 to the University of Wisconsin - Madison to investigate the molecular and cellular mechanisms of mutant ASXL1-driven clonal hematopoiesis, a pre-leukemic condition linked to aging and increased disease risk. The research aims to: 1) examine how the aged bone marrow microenvironment interacts with ASXL1 mutant hematopoietic stem cells to promote their expansion, and 2)...
This $680,334 federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) will support research to elucidate the molecular mechanisms and cellular players driving age-associated pro-tumoral myelopoiesis. The Icahn School of Medicine at Mount Sinai, the prime awardee, will conduct high-dimensional profiling of tumors from early-stage lung cancer patients, perform multi-omics phenotyping of myeloid cells and progenitors, and undertake complex bone...
This federal Project Grant award for $734,435.00, provided by the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research), supports research to overcome resistance to BH3 mimetic drugs in acute myeloid leukemia (AML). The key objectives are to: Correlate levels of the ADSS2 enzyme, which is involved in AMP biosynthesis, with BH3 mimetic responsiveness in primary AML patient samples, and determine if ADSS2 upregulation drives resistance through clonal selection. Define how...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to The Leland Stanford Junior University (Stanford University) totaling $153,696.00 aims to investigate the developmental origins and functional characteristics of myeloid-biased hematopoietic stem cells (MY-HSCs) that emerge during fetal development. The research will utilize advanced techniques such as flow cytometry, immunofluorescence, transplantation, and single-cell RNA sequencing to analyze the...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $146,922 to Rockefeller University to conduct research on the molecular determinants of the mRNA export platform and elucidate how age-associated mutations disrupt its assembly and lead to aberrant gene regulation. The key objectives are to: Generate a high-resolution integrative model of the mRNA export platform using single particle cryo-EM, biochemistry, mass spectrometry, and...