Project Grant R01AG082777

Award Date 9/15/24
Completion Date 8/31/29
Dollars Obligated $2.6M
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
North Carolina, USA
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This Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Pittsburgh aims to investigate the relationship between physical activity, pain, and motivation in older adults. The $268,040 award supports a 20-month study leveraging an existing longitudinal dataset to examine whether neural and behavioral measures of motivation can protect against physical activity decline in older adults with chronic pain. The research seeks to identify...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Wake Forest University Health Sciences provides $195,896 to enhance an ongoing weight loss study with older adults living with obesity. The key products and services include: Developing an automated image analysis platform to measure muscle quantity, quality, and changes over the 12-month study period using computed tomography (CT) scans of participants. Utilizing the CT data to develop...
This $748,180 Aging Research Project Grant (CFDA 93.866) awarded by the National Institute on Aging will fund a Stage 1A study to refine a caregiver-assisted pain coping skills training (PCST) intervention for patients with mild-to-moderate dementia and their caregivers. The study aims to (1) determine the optimal duration and delivery mode of the PCST intervention, and (2) identify effective recruitment and retention strategies, to prepare for a future Stage 2 randomized clinical trial. This...
This $616,809 Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) aims to optimize a remote-based physical activity intervention for adults with total knee replacement (TKR). The University of South Carolina, the prime awardee, will recruit nationwide participants to test the core "Energize!" exercise program, a 6-month fully automated internet-based program. Participants will also be randomized to receive 0-4 supplemental non-automated components,...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to evaluate the effects of adding morning bright light treatment to cognitive-behavioral therapy for insomnia in older adults undergoing total knee arthroplasty surgery. The $736,503 award, with a period of performance from August 1, 2024 to July 31, 2029, will fund a randomized controlled trial to determine if this combined insomnia treatment approach can prevent chronic post-surgical...
This federal Project Grant award of $421,329 from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund the development and preliminary testing of a peer narrative video intervention called "RECLAIM YOUR DAY" (RYD) for older adults with chronic musculoskeletal pain. The project, led by Butler Hospital, a division of the non-profit Care New England Health System, will create 6 video episodes featuring real patients sharing their experiences and strategies...
This federal Project Grant award was provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) to study the role of hyperalgesic priming in chronic pain management for the elderly. The $656,000 award will fund research at the University of California, San Francisco (UCSF) to: 1) Establish whether aged rats exhibit nociceptor plasticity (hyperalgesic priming) and if it is associated with systemic inflammation, and 2) Identify the underlying mechanisms of...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,365,011 to the University of Washington to investigate the mechanisms of mindfulness meditation (MM) and self-hypnosis (HYP) for reducing chronic pain in older adults. The study aims to use functional MRI and EEG to determine the neuromodulatory mediators and individual moderators of these non-pharmacological pain treatments. The 5-year project will enroll 375 older adults with chronic pain...
The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), has awarded Brandeis University a $148,568 Project Grant to conduct research on the neurobiological mechanisms underlying daily life activity participation in older adults and its relationship to Alzheimer's disease pathology. The project will employ a multilevel, multimodal framework to study the behavioral and neurobiological mechanisms driving age-related shifts in motivation to perform...
This federal Project Grant award for $2,366,213 was provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866). The purpose of the study, titled "IMPACT OF CHANGE IN LIFESTYLE HEALTH BEHAVIORS ON COGNITION: HARMONIZING AND LEVERAGING PARTICIPANT-LEVEL DATA FROM RANDOMIZED CONTROLLED TRIALS", is to examine how changes in lifestyle behaviors such as physical activity, cognitive activity, diet, and social engagement impact cognitive outcomes in...

The National Institute on Aging (CFDA 93.866 Aging Research) awarded a $2,617,270 Project Grant to Wake Forest University to conduct a 6-month remote behavioral intervention aimed at reducing pain, increasing physical activity, and promoting weight loss in older adults with chronic knee or hip osteoarthritic pain. The intervention will utilize a group-mediated approach rooted in social cognitive and self-determination theories, targeting increased daily steps, reduced sedentary time, and caloric restriction. The study will randomize participants to the intervention or an enhanced usual care control group, with an additional 6-month follow-up period to assess long-term outcomes. This Stage II R01 grant builds on previous pilot studies demonstrating the feasibility and potential benefits of the behavioral approach. The results will inform future real-world trials of this intervention targeting chronic pain and related health issues in the aging population.

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