This $6.18 million project grant from the National Institutes of Health's National Institute on Aging will fund the University of Texas at Austin to conduct the first large-scale genomic analysis of continuous rates of longitudinal aging-related cognitive change prior to dementia onset. Working with sub-awardees the University of Colorado and the University of Edinburgh, the researchers will identify genetic variants beyond APOE that confer risk for cognitive decline leading to eventual...
This $2,151,878 federal Project Grant award, funded by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), supports research at the University of North Carolina at Chapel Hill (UNC-CH) and its subrecipient, the University of Pennsylvania, to map the causal genetic-imaging-clinical pathway for Alzheimer's disease (AD). The key products and services to be delivered through this 3-year project include: Developing robust functional connectome analysis and causal...
This $310,000 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research by Texas Tech University Health Sciences Center (TTUHSC) to examine how alternative polyadenylation (APA) of mRNAs contributes to the development and progression of Alzheimer's disease (AD). The project has two main goals: 1) to identify APA genes and pathways associated with AD pathology using computational analysis of existing single-cell RNA-sequencing datasets, and 2)...
This federal Project Grant award, provided by the National Institute on Aging (NIA) under CFDA Program 93.866 - Aging Research, aims to examine the role of the environmental exposome as a risk factor for Alzheimer's disease (AD) among non-Hispanic Whites, African Americans, and Mexican Americans. The $1,205,827 award to the University of Texas Southwestern Medical Center will utilize blood samples from 3,000 participants in the ongoing Health & Aging Brain Study - Health Disparities Study...
This federal Cooperative Agreement award, with a total funding amount of $2,406,967.00, was provided by the National Institutes of Health's National Institute on Aging under the Aging Research grant program (CFDA 93.866). The award, with a start date of September 15, 2024 and an ultimate completion date of June 30, 2029, supports research to identify new genetic and molecular associations of Alzheimer's disease (AD) risk with the APOE ε2 and ε4 alleles. Key activities include: Conducting...
This $528,876 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will enable Emory University to investigate the cis- and trans-genetic regulation of brain transcriptomics and proteomics associated with Alzheimer's disease and Alzheimer's disease related dementias (AD/ADRD). The key products and services to be delivered include: Developing new analytical tools to integrate transcriptome-wide association studies (TWAS) and proteome-wide association studies...
The National Institute on Aging (NIA), part of the Department of Health and Human Services National Institutes of Health, awarded a $3.37 million Project Grant to The University of Texas at Arlington to develop an individualized deep connectome framework for Alzheimer's disease and related dementias (ADRD) analysis. The three-year grant, awarded on August 18, 2022 under the NIA's Aging Research program (CFDA 93.866), will support research to discover and identify individualized...
This $1,100,000 Project Grant was awarded by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to the University of Texas Medical Branch at Galveston (UTMB). The project aims to investigate the mechanisms by which amyloid-beta (Aβ) modulates the binding and internalization of pathogenic tau oligomers in human synapses, a key component of the trans-synaptic spread of tau pathology in Alzheimer's disease. Using innovative techniques to directly...
The National Institute on Aging (NIA) awarded a Project Grant (CFDA 93.866 - Aging Research) in the amount of $661,016 to the University of Southern California (USC) to develop a "Federated Deep Learning to Accelerate Alzheimer's Disease Research" project. The key products and services to be delivered include: Establishing an international "Federate AD" alliance to leverage innovative AI techniques and distributed computation to study Alzheimer's disease (AD) across large,...
This $107,948 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to enhance understanding of the biological signatures that distinguish subgroups of patients with Alzheimer's disease (AD). The key goals are to: Determine if AD subtypes can be identified solely using magnetic resonance imaging (MRI)-derived features through the application of machine learning algorithms. Integrate epigenetic profiles, including small non-coding RNA expression and DNA...