Project Grant R01AG081398

Award Date 9/30/24
Completion Date 6/30/29
Dollars Obligated $1.5M
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Houston, TX 77030, USA
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The University of Texas Health Science Center at Houston (UTHealth) was awarded a $1,493,584 Project Grant (R01AG081398) from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) to conduct research on identifying novel genetic risk factors for Alzheimer's disease and related brain imaging phenotypes. The project aims to develop efficient statistical and computational methods for genetic association mapping using identical-by-descent (IBD) segments, which can better capture haplotype effects than traditional genome-wide association studies. Specifically, the research will:

  1. Develop the statistical and computational framework for efficient IBD-based genetic association mapping in large samples (Aim 1).
  2. Apply IBD mapping to identify novel genomic regions associated with brain imaging endophenotypes from the UK Biobank (Aim 2).
  3. Replicate these associations in the Alzheimer's Disease Sequencing Project, develop and apply IBD mapping methods to Alzheimer's disease, and combine association evidence from diverse populations (Aim 3).

The University of Central Florida Board of Trustees will serve as a sub-grantee on this project, providing additional research support and expertise. The project is expected to run from September 2024 through June 2029.

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