Project Grant R01AG040220

The National Institute on Aging awarded a $1,590,410 Project Grant (CFDA 93.866 - Aging Research) to Indiana University Indianapolis to conduct a randomized controlled trial called "ADEPT-ICU: Attenuating Depression with Internet Cognitive Behavioral Therapy (CBT) to Slow Cognitive Decline in Older Intensive Care Unit (ICU) Survivors". The project aims to test the efficacy of an internet-based CBT intervention in reducing subjective cognitive decline, improving objective cognitive...

This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $123,530.00 to Trustees of Indiana University, doing business as Indiana University, for a project titled "Developing a Naturalistic Paradigm for Early Detection of Cognitive Impairment." The overarching goal of the 5-year project is to develop a naturalistic framework for the early detection of cognitive decline in older adults, leveraging a multimodal approach that examines...

This $2,366,213 federal project grant award from the National Institute on Aging (CFDA 93.866 Aging Research program) will fund the INLIFE (Individualized Lifestyle Change for Every Aging Brain) study. The purpose is to harmonize data from 12 U.S. randomized controlled trials covering 9,570 older adults to examine how changes in lifestyle health behaviors, such as physical activity, cognitive activity, diet, and social engagement, impact cognitive outcomes including memory, executive function,...

This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to discover and characterize novel tau proteoforms in blood that can differentiate healthy volunteers from patients with Alzheimer's disease (AD) or progressive supranuclear palsy (PSP), with the goal of enabling earlier diagnosis of tau pathology for these conditions. The $2,186,322 award to Trustees of Indiana University, doing business as Indiana University Indianapolis, will leverage samples...

This federal Project Grant award, totaling $817,345.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) grant program. The award aims to identify and understand the role of environmental stressors in the development of Alzheimer's Disease-Related Dementias (ADRD) and related health inequities across urban and rural populations in the state of Indiana. The...

The National Institute on Aging (NIA) has awarded a $784,998 Cooperative Agreement under the Aging Research program (CFDA 93.866) to Purdue University. The goal of this 5-year project is to identify and validate genetic risk factors that interact with developmental lead (Pb) exposure to contribute to the onset of Alzheimer's disease and related dementias (ADRD) in aging brain models. The project will establish and validate reporter systems to screen for ADRD pathogenic markers in 2D neuronal...

The Trustees of Indiana University, doing business as Indiana University Indianapolis (IU Indianapolis), was awarded a $725,000 Cooperative Agreement from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310). The objective of this 4-year award is to improve the recognition, access, and diagnostic evaluation for patients at risk of rare diseases in the state of Indiana. IU Indianapolis will leverage its expertise and...

This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $234,000.00 in funding to the University of Colorado-Denver to develop and pilot a patient decision aid (DA) to support shared decision-making between clinicians, patients, and caregivers regarding pharmacologic therapies for dementia. The key products to be delivered under this 2-year award include: 1) conducting a qualitative needs assessment among eligible patients, caregivers, and...

The National Institute of Neurological Disorders and Stroke (NINDS) has awarded a $433,218 federal Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to Indiana University Indianapolis. The funding will support research to study the role of the HUNK protein kinase in Alzheimer's disease (AD) pathology and cognitive dysfunction. The overarching goal is to determine whether HUNK is a druggable target for AD intervention. The project...

This $170,593 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) supports the development and pilot testing of a novel digital platform, called iPathD, to improve screening and access to treatment for depression among care partners of people living with Alzheimer's disease and related dementias. The project, led by Dartmouth-Hitchcock Clinic in collaboration with Dartmouth College, aims to optimize the iPathD platform to facilitate depression...