Project Grant R01AA033398
- The National Institute on Alcohol Abuse and Alcoholism awarded the University of Texas at Arlington $720,437 on May 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to conduct a hybrid Type 1 effectiveness-implementation trial evaluating parent-based interventions for adolescent alcohol prevention that incorporate social media content and personalized feedback. The research addresses the gap between evidence that alcohol parent-based interventions reduce adolescent drinking and the...
- The National Institute on Alcohol Abuse and Alcoholism awarded Texas A&M University System Health Science Center $635,002 on June 15, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate cholinergic modulation of striatal circuits in alcohol use disorder. The project examines how chronic alcohol intake affects acetylcholine signaling in the dorsomedial striatum, focusing on the interaction between direct-pathway medium spiny neurons and cholinergic interneurons. Research...
- The National Institute on Alcohol Abuse and Alcoholism awarded The University of Texas Health Science Center at San Antonio $664,792 on September 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate post-transcriptional mechanisms and cellular senescence in age-related alcoholic liver disease. The research targets dysregulated nutrient sensing as a hallmark of aging that drives hepatic steatosis progression toward cirrhosis and hepatocellular carcinoma. The recipient will...
- The National Institute on Alcohol Abuse and Alcoholism awarded The Johns Hopkins University $616,371 under the Alcohol Research Programs (CFDA 93.273) on June 10, 2026, to conduct a double-blind randomized controlled trial testing daridorexant, a dual orexin receptor antagonist, for reducing alcohol craving and use and improving total sleep time in patients with alcohol use disorder and co-occurring sleep disturbance. Participants recruited from a residential treatment facility will be...
- The National Institute on Alcohol Abuse and Alcoholism awarded The University of Texas Southwestern Medical Center $753,141 on August 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to conduct clinical and preclinical research on pregnenolone therapy for alcohol use disorder with co-occurring major depressive disorder. The recipient will evaluate pregnenolone, a naturally occurring neurosteroid available over the counter in the U.S., as a dual-indication treatment targeting both...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded $167,500 in Project Grant funding to the University of Massachusetts Medical School on September 17, 2025, through the Alcohol Research Programs (CFDA 93.273) for a research study investigating sex differences in excessive alcohol use patterns across young adulthood and middle age. The research will utilize longitudinal data from the National Longitudinal Study of Adolescent to Adult Health (Add Health) to examine how...
- The National Institute on Alcohol Abuse and Alcoholism awarded The University of Texas Southwestern Medical Center $702,746 on September 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate epigenetic regulation of endogenous retroviruses and alcohol-associated liver disease. The research will define mechanisms by which alcohol metabolism induces endogenous retrovirus (ERV) reactivation, reverse transcription, and innate immune activation, focusing on metabolic and...
- The National Institute on Alcohol Abuse and Alcoholism awarded the University of Texas Health Science Center at Houston $1.772 million on September 15, 2025, under the Alcohol Research Programs (CFDA 93.273) to develop and validate a microbial-based platform for assessing alcohol-related organ damage in alcohol use disorders. The recipient will develop a comprehensive web-based knowledge module integrating microbiota, metabolites, and host pathways to map microbial signatures and mechanisms...
- The National Institute on Alcohol Abuse and Alcoholism awarded the University of Texas at Dallas $555,966 on September 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate vagus nerve stimulation and cholinergic anti-inflammatory pathways in alcohol-associated liver disease pathogenesis. The funded research examines whether left cervical vagus nerve stimulation protects against alcohol-associated liver disease through activation of the α7 nicotinic acetylcholine receptor...
- The National Institute on Alcohol Abuse and Alcoholism awarded the University of Texas at Austin $160,988 on March 9, 2026, under the Alcohol Research Programs (CFDA 93.273) to support a project investigating the role of the gut microbiome in alcohol use disorder using a rodent model. The research employs high drinking in the dark mice (IHDID), a genetic model for heightened alcohol consumption, to explore whether gut microbial species are altered by alcohol exposure and whether the gut...
The National Institute on Alcohol Abuse and Alcoholism awarded the University of Texas at Arlington $596,443 on September 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to conduct a randomized controlled trial examining the effect of alcohol abstinence on cardiovascular disease risk factors. The research will enroll men and women who drink above recommended limits but are free of alcohol use disorder and cardiovascular disease. The study employs a novel alcohol abstinence intervention facilitated through a "know-your-number" approach and monitored via self-report questionnaires, alcohol biomarkers, and smartwatch-based technology. The trial measures blood pressure (in-laboratory and ambulatory central and peripheral) before and after the abstinence or control intervention; subclinical cardiovascular risk factors including arterial stiffness, endothelial function, and sympathetic nerve activity; and objective sleep patterns throughout study participation using wearable ring technology to investigate how alcohol reduction or abstinence influences sleep and the combined effects on blood pressure and subclinical cardiovascular risk factors. The project runs through August 31, 2031, with performance at the University of Texas at Arlington's Arlington, Texas campus. This is a Project Grant, the standard assistance type for research support under NIAAA's program, which funds research development spanning biomedical, genetic, psychological, environmental, and prevention domains related to alcohol and alcoholism.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $596.4k | 8/25/26 |