Project Grant R01AA033319
- The National Institute on Alcohol Abuse and Alcoholism, part of the Department of Health and Human Services National Institutes of Health, awarded $702,720 to Indiana University Indianapolis on August 10, 2026, under the Alcohol Research Programs (CFDA 93.273) project grant R01AA031671. The award funds research investigating posterior default mode network modulation as a treatment target in alcohol use disorder. The research examines how dysfunction in the medial posterior default mode...
- The National Institute on Alcohol Abuse and Alcoholism awarded Trustees of Indiana University (Indiana University Indianapolis) $138,118 on March 9, 2026, under the Alcohol Research Programs (CFDA 93.273) to conduct an integrative multi-omics study identifying cell-type and brain-region specific genetic drivers of alcohol use disorder. The recipient will perform differential expression and chromatin accessibility analyses using single-nucleus RNA-seq and ATAC-seq data from four brain regions...
- The National Institute on Alcohol Abuse and Alcoholism awarded Trustees of Indiana University (doing business as Indiana University Indianapolis) $760,785 under the Alcohol Research Programs (CFDA 93.273) on August 1, 2026. The award funds a pragmatic stepped-wedge cluster randomized trial testing infection mitigation measures (IMM) in patients with advanced alcohol-associated liver disease (AALD). The trial will enroll approximately 1,000 patients with AALD at four leading U.S. centers and...
- The National Institute on Alcohol Abuse and Alcoholism awarded Trustees of Indiana University (Indiana University Indianapolis) $492,012 on September 12, 2025, as a Project Grant under the Alcohol Research Programs (CFDA 93.273) to investigate the mechanism of neutrophilic NCF1 in alcohol-associated liver disease pathogenesis. The research examines how neutrophils drive disease severity and mediate liver injury in alcohol-associated liver disease (ALD), with specific focus on the NCF1 gene's...
- The National Institute on Alcohol Abuse and Alcoholism awarded the Trustees of Indiana University (Indiana University Indianapolis) $163,824 on May 4, 2026, under the Alcohol Research Programs (CFDA 93.273) as a Project Grant (K08 award K08AA032351). The award funds research and training on intergenerational trauma and youth alcohol use, specifically examining how maternal post-traumatic stress disorder affects youth neurobiology and alcohol consumption. The principal investigator will acquire...
- The National Institute on Alcohol Abuse and Alcoholism awarded the University of Pittsburgh $903,936 on September 20, 2025, under the Alcohol Research Programs (CFDA 93.273) to investigate mechanisms of alcohol's effects on prefrontal cortex circuits, with performance through July 31, 2030, in Pittsburgh, Pennsylvania. The research examines how vasoactive intestinal peptide–expressing inhibitory interneurons (VIP-INs) in the prefrontal cortex modulate drinking behavior and affective changes in...
- This Project Grant award of $223,932, obligated on August 31, 2025, supports neuroscience research conducted by Indiana University Indianapolis under the Alcohol Research Programs (CFDA 93.273), administered by the National Institute on Alcohol Abuse and Alcoholism. The research targets parvalbumin inhibitory interneurons to elucidate the neural circuit mechanisms underlying impulsivity and its relationship to genetic risk for excessive drinking. The project investigates how specific cell...
- The National Institute on Alcohol Abuse and Alcoholism awarded Northwestern University $100,228 on December 18, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate projection-specific endocannabinoid signaling mechanisms in ethanol-related behaviors. The research examines how ethanol affects endocannabinoid-cannabinoid receptor type 1 signaling at dorsolateral striatum terminals in the external segment of the globus pallidus, and how altered signaling at these terminals...
- The National Institute on Alcohol Abuse and Alcoholism awarded Trustees of Tufts College $686,774 on July 20, 2026, under the Alcohol Research Programs (CFDA 93.273) to conduct behavioral neurobiology research on stress, alcohol responsivity, and alcohol drinking patterns. The research uses rodent models to investigate how stress exposure alters sensitivity to alcohol's aversive effects and the neural circuits involved. The study employs classical and operant conditioning paradigms combined with...
- The National Institute on Alcohol Abuse and Alcoholism awarded Vanderbilt University $314,616 on January 25, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate cell-type-specific neural mechanisms underlying alcohol-associated behavior in the striatum. The research elucidates how D2-receptor-containing medium spiny neurons in the nucleus accumbens encode associations between alcohol-related cues and outcomes, and how chronic alcohol exposure and abstinence alter these...
The National Institute on Alcohol Abuse and Alcoholism awarded Trustees of Indiana University, doing business as Indiana University Indianapolis, $381,363 on August 20, 2026, under the Alcohol Research Programs (CFDA 93.273) to support research on inhibitory corticostriatal circuit mechanisms underlying binge alcohol drinking. The award funds investigation of how alcohol alters synaptic function in neural circuits that contribute to alcohol use disorder progression, specifically focusing on the dorsal striatum's role in goal-directed learning and habit formation. The research examines synaptic changes induced by alcohol in connections from the anterior insular cortex to the dorsolateral striatum, including both presynaptic alterations in mu opioid receptor-mediated plasticity and postsynaptic increases in glutamate receptor function within medium spiny neurons. The project employs in vivo optogenetic methods to evaluate circuit activation effects on alcohol consumption and investigates long-range cortical GABAergic inhibitory projections, particularly from parvalbumin-expressing neurons in the anterior insular cortex that send direct inhibitory synapses to the dorsolateral striatum. The period of performance runs from August 20, 2026, through May 31, 2031, with work performed in Indianapolis, Indiana. This assistance type is a project grant supporting basic research to develop knowledge applicable to improved treatment methods and prevention strategies for alcoholism and alcohol-related problems.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $381.4k | 8/19/26 |