Project Grant R01AA032548
- This federal Project Grant award for $357,613 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to leverage large-scale whole-genome sequencing (WGS) data to identify novel rare and common genetic variants associated with substance use disorders (SUDs). The project, awarded to Yale University, has two key objectives: 1) to recover missing heritability in SUDs by analyzing WGS data from biobanks, and 2) to develop a novel...
- This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) program, supports a $559,180 research project to investigate neurobiological factors underlying Alcohol Use Disorder (AUD) with and without comorbid cigarette smoking. The project aims to identify AUD-associated differences in DNA methylation and RNA expression in the nucleus accumbens and dorsolateral prefrontal cortex, key brain regions...
- This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), provides $248,844 to the University of North Carolina at Chapel Hill (UNC-CH) for research on the use of blood-based RNA biomarkers to diagnose and monitor Alcohol Use Disorder (AUD). The research aims to determine whether blood gene expression profiles can serve as a non-invasive proxy for brain tissue to aid in personalized medicine approaches...
- This Project Grant award, valued at $2,250,249.00 and funded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), supports a research project conducted by the University of California, San Diego (UCSD) to investigate brain features associated with alcohol use disorder (AUD). The project aims to employ longitudinal multi-parametric magnetic resonance imaging (MRI) to assess baseline brain characteristics and changes following alcohol...
- This federal Project Grant award of $396,643 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) supports research to elucidate the mechanisms underlying stress-potentiated ethanol drinking. The project aims to investigate the role of the histone methyltransferase G9a and its effects on dynorphin-positive neurons in the nucleus accumbens to regulate this behavior. Key objectives include testing the hypothesis that G9a's effects on...
- This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) provides $3,168,729 to New York University to conduct a collaborative research project titled "A Translational Approach for Novel Precision Medicine Models." The project aims to identify novel molecular targets and mechanisms of treatment responses in alcohol use disorder (AUD) based on the role of mitochondrial metabolism and epigenetic...
- This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (CFDA 93.273 - Alcohol Research Programs) provides $171,178 to the University of California, Los Angeles (UCLA) to investigate the fundamental genetic and epigenetic mechanisms underlying the transgenerational effects of alcohol exposure. The overarching goal is to reveal how the "memory" of alcohol exposure is encoded and transmitted across generations in the nervous system. The research will leverage...
- This federal Project Grant award for $700,000.00, issued by the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program, supports research to investigate the neurophysiological and genetic factors contributing to binge drinking and alcohol use disorder. The primary awardee, the University of New Mexico (UNM) Health Sciences Center, will leverage techniques such as monosynaptic circuit labeling, optogenetics, electrophysiology,...
- This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA, CFDA 93.273 Alcohol Research Programs) provides $647,330 to Wake Forest University Health Sciences to conduct research on the role of epigenetics in predisposing the brain to risky alcohol use. The researchers will perform a longitudinal genome-wide DNA methylation analysis of the rhesus macaque dorsolateral prefrontal cortex to identify biomarkers associated with future alcohol drinking levels. The goal...
- This Project Grant award, totaling $560,108.00 and spanning September 15, 2025 to August 31, 2030, was provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) federal grant program. The purpose of the project is to investigate the neurocognitive mechanisms that promote resilience to alcohol use disorder (AUD) in individuals with a family history of AUD. Specifically, the research will examine how attentional abilities may...
This Project Grant award of $1,999,225.00 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will fund a whole-genome sequencing study to improve the understanding of the genetic mechanisms underlying alcohol use disorder (AUD). The study aims to uncover novel rare, common, and structural genetic variants associated with AUD, identify causal variants through cross-ancestry fine-mapping to improve disease prediction, and map the sequencing results to single-cell RNA sequencing data to identify key brain cell subtypes and processes involved in AUD. This innovative research leverages large-scale whole-genome sequencing data from biobanks, publicly available single-cell data, and advanced statistical methods to address critical gaps in the current understanding of the genetic factors underlying AUD. The award was made to Yale University, and the project will be conducted from September 2025 through August 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.0m | 9/10/25 |