Project Grant R01AA032254
- This $856,625 Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), supports an exploratory randomized controlled trial (RCT) of the effects of oral semaglutide on alcohol craving and consumption. The University of Colorado-Denver, as the prime awardee, will conduct this 2-year study to assess the safety, tolerability, and efficacy of semaglutide, a glucagon-like peptide-1 (GLP-1) agonist, compared to placebo...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), awarded a $901,666 Project Grant to Research Triangle Institute (RTI International) to develop small molecule modulators of the RXFP3 receptor as potential therapeutic agents for alcohol use disorder (AUD). The project aims to further optimize and evaluate the effectiveness of the RXFP3 negative allosteric modulators (NAMs) RLX-33 and RLX-79 in animal models of alcohol...
- This Project Grant award was provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), which falls under the federal Alcohol Research Programs (CFDA 93.273). The $692,723 award will support a double-blind, placebo-controlled clinical trial to test whether the drug suvorexant can be used as a novel therapeutic for alcohol use disorder (AUD) and stress-related drinking. The 5-year project, running from September 2025 through August 2030, will be conducted by researchers at The...
- This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) provides $3,168,729 to New York University to conduct a collaborative research project titled "A Translational Approach for Novel Precision Medicine Models." The project aims to identify novel molecular targets and mechanisms of treatment responses in alcohol use disorder (AUD) based on the role of mitochondrial metabolism and epigenetic...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), awarded a $390,454 Project Grant to Envisbio LLC to develop novel therapeutic aptamers targeting phosphodiesterase 4B (PDE4B) for the treatment of alcohol use disorder (AUD). The project aims to identify and characterize PDE4B-specific aptamers that can modulate PDE4B activity, with the goal of advancing these modulators into in vivo testing and eventual human clinical trials for...
- This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will support a research study examining emotion regulation strategy use in an outpatient treatment program for adolescents with co-occurring alcohol use disorder (AUD) and psychiatric diagnoses. The $248,770 award, made on September 25, 2025, will fund a pilot study to test the feasibility and acceptability of an ecological momentary assessment (EMA)...
- This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) program, is for a $735,930 feasibility and acceptability study of a large language model-based conversational agent for brief alcohol intervention among emerging adults (ages 18-29). The award will support the development, validation, and open trial of a conversational agent-delivered brief intervention designed to reduce alcohol use and problems...
- This federal Project Grant award, funded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), will support research on the role of somatostatin in the central amygdala in relation to heavy alcohol drinking. The research team at Boston University Medical Campus will use an animal model of heavy alcohol drinking, combined with pharmacological, molecular, and electrophysiological approaches, to test the hypothesis that activation of...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $1,742,166 Project Grant under CFDA 93.273 - Alcohol Research Programs to the Trustees of Boston University, doing business as Boston University Medical Campus. The grant supports a comprehensive evaluation to assess the associations of state alcohol taxation and related policy environment with state-level alcohol treatment facilities capacity and key alcohol use disorder (AUD) health service outcomes. The project...
- This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), provides $248,844 to the University of North Carolina at Chapel Hill (UNC-CH) for research on the use of blood-based RNA biomarkers to diagnose and monitor Alcohol Use Disorder (AUD). The research aims to determine whether blood gene expression profiles can serve as a non-invasive proxy for brain tissue to aid in personalized medicine approaches...
This Project Grant award, totaling $755,539, was provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273). The funding will support research conducted by Emory University to evaluate the real-world utilization, effectiveness, and safety of glucagon-like peptide-1 receptor agonists (GLP-1RAs) as a treatment for alcohol use disorder (AUD). The project aims to leverage administrative claims data and linked electronic health records to generate comparative evidence on the use of GLP-1RAs versus other AUD medications in clinical practice, with a focus on assessing outcomes in older, rural, and racially/ethnically diverse populations. The award period runs from September 10, 2025 to May 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $755.5k | 9/9/25 |