The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $438,375 Project Grant under the Alcohol Research Programs (CFDA 93.273) to Cedars-Sinai Medical Center to establish a human liver-on-a-chip model for studying alcohol-associated liver disease (ALD). The 2-year project, starting September 2023, aims to investigate the roles of liver sinusoidal endothelial cells and acetaldehyde metabolism in regulating ethanol-induced liver damage as well as the contribution of fibrotic...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $537,587 Project Grant under the Alcohol Research Programs (CFDA 93.273) to The University of Texas Southwestern Medical Center to conduct research on the metabolic consequences of liver inflammation on alcohol consumption and alcohol-associated liver disease (ALD). The key objectives are to identify the mechanisms by which the transcription factor IRF3 suppresses the expression and secretion of the metabolic regulator...
This federal Project Grant award of $380,863 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), supports research on the role of specific hepatic stellate cell subsets in the progression of alcohol-associated hepatitis (AH). The project aims to determine how the genes CYP1B1, PRRX1, and NR4A2 regulate the development and function of a novel FBLN2+ activated hepatic stellate cell (AHSC) subset in AH. Planned activities include...
This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will provide $119,600 over a 3-year period from July 2024 to July 2027 to the University of Kansas Medical Center Research Institute, Inc. (KUMCRI) to conduct research on the mechanisms by which aging and alcohol consumption cooperatively contribute to the development of alcohol-associated liver disease (ALD). The project aims to identify how...
This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), provides $688,199 to Yale University to conduct research on the role of non-parenchymal cells in driving the key features of alcohol-associated hepatitis (AAH) in a fully humanized mouse liver model. The study aims to examine specific ligand-receptor interactions between non-parenchymal cells and human hepatocytes that may be responsible for...
This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the federal Alcohol Research Programs (CFDA 93.273), provides $1,158,934.00 to the University of Kansas Medical Center Research Institute, Inc. over a period from August 20, 2024 to May 31, 2029. The project aims to investigate the mechanisms by which chronic alcohol exposure leads to the formation of dysfunctional megamitochondria in the liver, and how this contributes to alcohol-associated liver...
This $442,898 Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will support research to define the contributions of macrophage migration inhibitory factor (MIF) and its receptor CD74 in alcohol-associated liver disease (ALD). The research plan includes three specific aims: 1) characterizing the role of CD74 expression in hepatocytes and myeloid cells during and after ethanol feeding in mice, 2) resolving the...
This Project Grant award of $374,598.00, awarded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), supports research to investigate the impact of alcohol consumption on RNA chemical modifications and their contribution to the development and progression of alcohol-associated liver disease (ALD). The University of Louisville will treat mice with alcohol and map the chemical modifications on different types of RNAs isolated from...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $1,547,718 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of Kansas Medical Center Research Institute, Inc. (KUMCRI) to investigate the role of KDM5 demethylases in alcohol-associated liver disease (ALD) development and resolution. The project aims to determine the sex-specific and sex-independent functions of KDM5B and KDM5C in mediating cellular crosstalk in ALD, define the mechanism...
This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, will support the development and testing of a novel in vivo model called CHIMERA-BONCAT. This model will enable comprehensive, unbiased, and cell-type-specific characterization of the human microglial response to alcohol exposure. The $214,385 award, with a period of performance from August 2024 to July 2026, will fund research...