This Project Grant award from the National Institute on Aging's (NIA) Aging Research program (CFDA 93.866) provides $660,402 to the University of Maryland, Baltimore (UMB) to study the role of autophagy, a cellular process that recycles damaged components, in regulating lipid metabolism and inflammation in microglia during brain aging and neurodegenerative diseases like Alzheimer's disease (AD). The research aims to determine how microglial lipid phagocytosis inhibits autophagy, leading to...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $433,824 to the J. David Gladstone Institutes in San Francisco, CA to investigate how the Alzheimer's disease risk factor APOE4 disrupts the maturation and integration of adult-born dentate granule cells in the hippocampus. The research aims to elucidate the underlying transcriptomic changes and electrophysiological alterations that lead to hyperexcitability in these neurons, with the...
This $652,188 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research at the University of Pennsylvania to investigate cell-type-specific regulation of autophagy and lysosomal pathways within and between astrocytes and neurons under proteotoxic stress from alpha-synuclein aggregation. The goal is to elucidate how differences in quality control mechanisms between these cell types may contribute to the preferential vulnerability of neurons...
The Project Grant award R01AG079283, funded by the National Institute on Aging (CFDA 93.866 Aging Research program), will support research on the characterization of amyloid protein aggregation and its interactions with apolipoprotein E (APOE) in the context of Alzheimer's disease. The $748,641 award, with a project period from May 2024 to April 2029, will utilize advanced mass spectrometry-based protein footprinting techniques, including hydrogen/deuterium exchange and fast photochemical...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to investigate how Alzheimer's disease pathogenesis interferes with synaptic autophagy, and evaluate if optimizing synaptic autophagy can be neuroprotective in an Alzheimer's mouse model. The $628,000 award to Rutgers, The State University of New Jersey, will utilize primary hippocampal cell cultures and mouse models to study the disruption of autophagic processing of synaptic proteins in...
This $4.2 million project grant from the National Institutes of Health's National Institute on Aging will fund research into the mechanisms by which the ABCA7 gene influences Alzheimer's disease. The Trustees of the University of Pennsylvania will investigate the specific lipid species affected by deletion of ABCA7 in three types of induced pluripotent stem cell-derived brain cells. Researchers will also identify ABCA7 protein domains that differentiate its functions from ABCA1 and...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $871,093 to the Sloan-Kettering Institute for Cancer Research to elucidate the mechanisms underlying the regulation of the transcription factor EB (TFEB) and the autophagy-lysosomal pathway (ALP), and to investigate their therapeutic potential as mechanism-based treatments for Alzheimer's disease (AD). The research aims to determine how the protein phosphatases CDC25A and PP2A regulate TFEB...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $749,030 in funding to The Trustees of Columbia University in the City of New York to conduct research on the mechanisms responsible for autophagy defects in neurons affected by Alzheimer's disease (AD).
The key goals of this 5-year project are to: 1) evaluate the effects of clinically relevant ryanodine receptor type 2 (RyaR2) inhibitors, positive allosteric modulators of the...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $4,151,128 to The Winifred Masterson Burke Medical Research Institute, Inc. to investigate the role of neuronal hyperexcitability and proteostasis (protein homeostasis) in the pathogenesis of Alzheimer's disease. The 5-year project, which began on September 1, 2024, aims to elucidate how modifications in brain activity, particularly in the locus coeruleus and hippocampus, can lead to...
This $143,135 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to investigate the role of short tandem repeat (STR) expansions in the development and progression of Alzheimer's disease (AD). The principal investigator will utilize existing whole genome sequencing data from over 11,000 AD cases and controls to test whether STR expansions correlate with age of onset and rate of disease progression (Aim 1). They will then assess somatic STR instability...