Project Grant R00HL175029
- The National Heart, Lung, and Blood Institute awarded Florida International University $777,999 on June 10, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to support research on airway epithelial defense mechanisms in combating STAT3-deficiency-related lung infections. The project investigates how downregulated STAT3 expression increases susceptibility to recurrent infections, particularly pneumonia and multidrug-resistant Pseudomonas aeruginosa, with focus on airway...
- The National Heart, Lung, and Blood Institute awarded the University of Florida $159,560 on December 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to support postdoctoral research training on ENAMPT targeting to modulate brain and lung injury following traumatic brain injury exposure. The award funds a postdoctoral fellow's research exploring the role of extracellular nicotinamide phosphoribosyltransferase (eNAMPT) in mediating traumatic brain injury (TBI)-mediated...
- The National Heart, Lung, and Blood Institute awarded the University of Florida $688,383 under the Cardiovascular Diseases Research program (CFDA 93.837) on September 1, 2026, to support preclinical and translational research on mitochondrial efficiency in peripheral artery disease. The project, titled "Enhancing OXPHOS Efficiency to Promote Muscle Function and Regeneration in Peripheral Artery Disease," will develop strategies to optimize leg muscle oxidative metabolism in PAD...
- The National Heart, Lung, and Blood Institute awarded the University of Florida $142,568 on June 1, 2026, through the Cardiovascular Diseases Research program (CFDA 93.837) to support career development of a mathematician-data scientist applying machine learning to predict early and chronic graft dysfunction after lung transplantation. The research integrates clinical and biological markers from donors and recipients to identify and validate predictors of primary graft dysfunction (PGD)...
- The National Heart, Lung, and Blood Institute awarded the University of Florida $597,817 on August 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop resources for enhancing hematopoietic stem cell transplantation outcomes. The research aims to humanize the bone marrow vascular niche to study hematopoietic stem cell and vascular interactions and function. The project will establish technologies to isolate and cultivate human primary endothelial cells from bone...
- The National Heart, Lung, and Blood Institute awarded Louisiana State University Health Sciences Center-Shreveport $111,111 on August 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate mechanisms linking endoplasmic reticulum stress, lipid accumulation, and vascular inflammation in atherosclerosis. The research defines how the NCK1 adaptor protein integrates mechanical and metabolic stress to drive endothelial dysfunction. Aim 1 investigates how NCK1...
- The National Heart, Lung, and Blood Institute awarded the University of Pennsylvania $157,658 on June 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837, K99HL185935) to elucidate mechanical regulation of the lung gas exchange interface through investigation of how capillary endothelial cells and alveolar epithelial cells respond to biophysical strain during breathing. The award funds research into mechanically induced capillary endothelial cells (MICAPs) identified in...
- The National Institutes of Health National Heart Lung and Blood Institute awarded New York University $201,728 on March 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct research examining mechanisms contributing to functional recovery across the care cascade for respiratory failure. The research addresses how patient-level social determinants recorded at hospital admission, unit-level care processes during hospitalization, and community-level environmental...
- The National Heart, Lung, and Blood Institute awarded the Trustees of Boston University $712,630 on August 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate functional heterogeneity of alveoli and early responses to airborne agents. The recipient will develop and apply the Crystal Ribcage, a novel intravital imaging platform, to visualize real-time, high-resolution dynamics of the intact, ventilating lung. The research will define the anatomy, physiology,...
- The National Institute of Neurological Disorders and Stroke awarded the University of Florida $592,967 on August 17, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to optimize therapeutic acute intermittent hypoxia (TAIH) as a treatment for improving breathing and motor function after cervical spinal cord injury. The research investigates temporal variation in TAIH efficacy across injury phases—sub-acute, early-chronic, and...
The National Heart, Lung, and Blood Institute awarded the University of Florida $249,000 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct research into how genetic factors, specifically apolipoprotein E4 (APOE4) alleles and inflammation, influence respiratory plasticity mechanisms. The research builds on prior K99 phase work and investigates phrenic long-term facilitation (PLTF), a prolonged increase in phrenic motor output triggered by moderate acute intermittent hypoxia. The R00 phase aims to understand the role of APOE4 in phrenic motor neuron microglia signaling and how acute inflammation affects these interactions. The research targets mechanisms that undermine PLTF, with the goal of identifying molecular targets for precision interventions to optimize therapeutic efficacy in clinical trials aimed at preserving or restoring breathing ability in people with spinal cord injury and amyotrophic lateral sclerosis. During the prior K99 phase, the applicant completed portions of the original proposal, gained technical skills, and secured a tenure-track assistant professor position in the Department of Neuroscience at the University of Florida. Work is performed in Gainesville, Florida. The award period runs from September 1, 2026, through July 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 8/17/26 | ||
| Not listed | $249.0k | 8/10/26 |