This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $779,952 to Thomas Jefferson University, doing business as Sidney Kimmel Medical College, for a research project titled "Platelets as Regulator of Non-Neurological Complications of Ischemic Stroke". The project aims to elucidate the role of activated platelets in remote organ injury and infection following ischemic stroke/reperfusion, determine...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $685,884 to the University of North Carolina at Chapel Hill to conduct research on the regulation of coagulation and thrombosis by C1 inhibitor. The research aims to elucidate the molecular mechanisms by which endogenous C1 inhibitor regulates coagulation and venous thrombosis, evaluate the impact of C1 inhibitor deficiency on coagulation...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $810,875 to The Trustees of the University of Pennsylvania to develop two novel chimeric antigen receptor (CAR) T cell strategies to selectively deplete autoantibody-secreting B cells as a potential curative treatment for acquired thrombotic thrombocytopenic purpura (ITTP), a life-threatening autoimmune disorder. The award aims to conduct in-depth preclinical...
This federal Project Grant award of $942,492 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research at Rush University Medical Center to investigate silent brain infarcts (SBIs) as a potential biomarker for vascular contributions to cognitive impairment and dementia (VCID) in survivors of spontaneous intracerebral hemorrhage (SICH). The key objectives...
This federal Project Grant award from the National Center for Advancing Translational Sciences (NCATS), CFDA #93.350, aims to develop a consensus-driven measurement strategy for assessing cognitive function in patients with thrombotic thrombocytopenic purpura (TTP), a rare and life-threatening blood disorder. The $456,348 award to Duke University, scheduled to be completed by July 31, 2026, will fund a study to determine the impacts of TTP on cognitive function and establish a rigorous...
This federal Project Grant award, provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), aims to adapt and preliminarily test an individualized care plan (ICP) prototype for inpatient sickle cell disease (SCD) vaso-occlusive episode (VOE) care. The total award amount is $191,792.00 over the project period of September 17, 2024 to August 31, 2029. The key objectives are to: 1) develop an ICP prototype adapted from the...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $834,531 to The General Hospital Corporation (doing business as Massachusetts General Hospital) to investigate the effects of IL-1 beta inhibition on vascular inflammation in individuals with clonal hematopoiesis of indeterminate potential (CHIP), an emerging atherosclerotic cardiovascular disease risk factor. The study will enroll 120 participants to assess...
This $131,250 Project Grant was awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The grant will support a research project led by Vitalant Research Institute (VRI) to investigate the potential for transfusion-transmitted cerebral amyloid angiopathy (CAA). The key objectives are to: (A) assess the prevalence of amyloid-beta pathology among blood donors using the PTAU217 protein marker, and (B)...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $1,485,606 in funding to The Johns Hopkins University to conduct a comprehensive research project titled "Lipoprotein (A) Modification of the Impact of HIV Infection on Atherosclerotic Cardiovascular Disease". The project aims to identify lipoprotein(a) risk thresholds, explore mechanisms linking lipoprotein(a) to heightened cardiovascular disease risk...
This $624,583 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research at the University of Washington to identify potential therapeutic targets for preventing ischemic stroke. The project will leverage existing plasma samples, genomic data, and electronic medical records from the Heart and Vascular Health Study to evaluate...