Project Grant R00HL171873
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded The Johns Hopkins University a Project Grant of $638,176 (Award Date: May 1, 2026; Completion Date: February 28, 2029) under the Cardiovascular Diseases Research program (CFDA 93.837). This grant funds basic research investigating thrombospondin-1 (TSP-1), a matricellular protein, as a therapeutic target for treating heart failure with preserved ejection fraction (HFpEF). The research will examine the...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Massachusetts General Hospital a $614,843 Project Grant (CFDA 93.837: Cardiovascular Diseases Research) effective May 1, 2026, through February 28, 2031, to conduct research on indexed exercise blood pressure and its relationship with adverse vascular and ventricular remodeling. The research aims to investigate whether the ratio of systolic blood pressure to oxygen consumption (SBP/VO2) during exercise...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded The Johns Hopkins University a $514,484 Project Grant (CFDA 93.837: Cardiovascular Diseases Research) on August 24, 2025, for research investigating the role of kynurenine pathway metabolism in pulmonary arterial hypertension (PAH). The research will be conducted through June 30, 2030, at Johns Hopkins' Maryland facilities. The project delivers basic and translational research services focused on...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Texas Southwestern Medical Center a $249,000 Project Grant (CFDA 93.837 – Cardiovascular Diseases Research) effective August 1, 2025, through June 30, 2028, to conduct research investigating the mechanisms of dyspnea on exertion (DOE) and exercise intolerance in patients with heart failure with preserved ejection fraction (HFpEF). The research will examine how obesity-related mechanical...
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $242,250 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 1, 2025, with completion targeted for August 31, 2027. This feasibility study (R03 mechanism) implements arteriovenous blood sampling techniques to measure regional metabolic changes in the heart and legs during submaximal exercise...
- Federal Grant Award Summary The Johns Hopkins University received a $245,624 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 5, 2025, with completion targeted for August 31, 2027. This secondary data analysis project applies unsupervised machine learning methodologies to identify novel patient clusters within existing pulmonary hypertension datasets, specifically focusing on systemic...
- Federal Grant Award Summary The University of Kansas Medical Center Research Institute, Inc. received a $774,997 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 1, 2025 through May 31, 2029. The award funds research investigating the contribution of medullary pre-sympathetic neurons to breathing disorders and autonomic dysfunction in heart failure with preserved ejection fraction...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a Project Grant totaling $811,885 to the J. David Gladstone Institutes under the Cardiovascular Diseases Research program (CFDA 93.837) on September 12, 2025. The award funds research to elucidate epigenomic mechanisms of cardiac fibrosis and heart failure pathogenesis, with a completion date of May 31, 2029. The research leverages novel genetic mouse models, advanced transcriptional and epigenomic...
- Federal Grant Award Summary The Medical University of South Carolina received a Project Grant award of $188,568 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective April 1, 2026 through March 31, 2031. This award supports research investigating regional disparities in skeletal muscle microvascular dysfunction (MVD) in systolic heart failure patients, with a focus on understanding why exercise intolerance...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded $169,020 in Project Grant funding to the University of Pennsylvania, effective August 1, 2025, through June 30, 2027, under the Cardiovascular Diseases Research program (CFDA 93.837). The award supports research investigating one-carbon metabolism defects in heart failure, with the primary deliverable being scientific research outputs aimed at understanding the relationship between aberrant cardiac...
The National Heart, Lung, and Blood Institute (NHLBI) awarded The Johns Hopkins University a $248,919 Project Grant effective June 1, 2026 through April 30, 2029 under the Cardiovascular Diseases Research program (CFDA 93.837). This research initiative investigates muscle metabolism and exercise intolerance in patients with heart failure with preserved ejection fraction (HFpEF), the fastest-growing form of heart failure. The project will utilize novel interleaved magnetic resonance spectroscopy/magnetic resonance imaging (MRS/MRI) methodology to simultaneously measure skeletal muscle metabolism and peripheral blood flow during exercise, addressing a critical gap in understanding whether impaired exercise capacity in HFpEF patients results from primary mitochondrial oxidative metabolism deficiencies or secondary limitations in peripheral blood flow. The research will also evaluate the impact of sodium-glucose cotransporter-2 inhibitors (SGLT2i)—a clinically available metabolic modulator—on muscle metabolism in HFpEF patients. Additionally, this project will employ wearable health technology to measure exercise intolerance and sedentary behavior during activities of daily living, establishing relationships between these real-world functional measures and skeletal muscle energetics. These research deliverables are designed to enhance understanding of HFpEF pathophysiology and identify potential therapeutic interventions to improve exercise tolerance and quality of life in this patient population.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $248.9k | 5/26/26 |