Project Grant R00HL169909
- Summary of Federal Project Grant Award The University of Colorado-Denver received a $150,104 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective January 26, 2026, with a completion date of December 31, 2028. The research project investigates lysine myristoylation as a novel mechanism for regulating protein kinase A (PKA) in cardiac tissue, with the objective of developing alternative...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a Project Grant of $553,217 to the Regents of the University of Colorado-Denver under the Cardiovascular Diseases Research program (CFDA 93.837) effective August 15, 2025, with a completion date of May 31, 2029. This research initiative, titled "Hat-Dependent Control of Cardiac Fibrosis," focuses on investigating the role of histone acetyltransferases (HATs), specifically P300 and CREB-binding...
- Federal Grant Award Summary The University of Colorado-Denver received a $234,000 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded on March 10, 2025, with completion anticipated by December 31, 2026. This grant supports secondary analysis of three-dimensional echocardiography (3DE) images to compute three-dimensional surface strain measurements of the right ventricle. The project develops and...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a Project Grant of $111,626 to The Regents of the University of Colorado (University of Colorado-Denver) under the Cardiovascular Diseases Research program (CFDA 93.837) effective August 1, 2025, through July 31, 2027. This research initiative addresses pulmonary hypertension (PH) associated with sickle cell disease (SCD) by investigating the role of macrophage populations in disease progression. The...
- Federal Grant Award Summary Colorado State University received a $1,311,770 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 15, 2025, with completion anticipated by June 30, 2030. The project delivers research services focused on developing and validating Electrical Impedance Tomography (EIT) as a noninvasive diagnostic tool for assessing respiratory function in patients with...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $744,880 Project Grant to The Regents of the University of Colorado (University of Colorado-Denver) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 1, 2025, through May 31, 2029. The award supports fundamental research investigating epimetabolic regulation of macrophage activation during acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). The...
- Federal Grant Award Summary The University of Wisconsin–Madison received a $151,040 Project Grant award dated February 5, 2026, from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) to support basic scientific research investigating the assembly and localization of human ether-à-go-go-related gene (hERG) channel cotranslational complexes. The research examines how cardiac ion channels are co-regulated during protein...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the Regents of the University of Colorado-Denver a $429,000 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) for a two-year period from September 1, 2025 through August 31, 2027. The project investigates selective vagal neuromodulation as a potential therapeutic approach to improve heart failure treatment outcomes. Using optical neuromodulation techniques and custom...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded The Regents of the University of Colorado (University of Colorado-Denver) a Project Grant of $702,308 under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 1, 2025, with completion targeted for June 30, 2029. The award supports mechanistic research into airway mucin glycosylation and the regulation of mucin function and dysfunction in pulmonary health and disease. The...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded $163,145.00 to The Regents of the University of Colorado (University of Colorado-Denver) under the Cardiovascular Diseases Research program (CFDA 93.837) for a five-year project period beginning September 1, 2025 and concluding August 31, 2030. This Project Grant supports investigator-initiated research examining sex differences in cardiac macrophages in response to pulmonary hypertension (PH)....
The University of Colorado-Denver received a $249,000 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded February 16, 2026, with completion targeted for January 31, 2029. The grant supports basic science research investigating the biogenesis and assembly mechanisms of human ether-a-go-go-related gene (HERG1) ion channels in cardiomyocytes. The research deliverables include characterization of messenger ribonucleic acid (mRNA) structural features that promote co-translational association of HERG1A and 1B channel subunits, quantification of RNA-RNA interaction affinities and energetic parameters, and evaluation of RNA-binding proteins DDX3X and DDX5 roles in regulating mRNA stability, translation, and subunit assembly using specialized molecular and cellular techniques. The project employs advanced methodologies including isothermal titration calorimetry (ITC), protein-RNA immunoprecipitation (RIP), quantitative polymerase chain reaction (qPCR), ribosome profiling, electrophysiology, and single-molecule fluorescent in situ hybridization (smFISH) to deliver comprehensive findings on ion channel assembly mechanisms in human induced pluripotent stem cell-derived cardiomyocytes and human myocardium. These research products will advance understanding of cardiac potassium current regulation and may inform strategies to address pro-arrhythmic cellular behaviors resulting from imbalanced HERG1A/1B subunit expression.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $249.0k | 2/12/26 |