Project Grant R01HL175869
- This Project Grant award of $807,067.00 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) will support a study to pioneer the quantitative documentation of human respiratory kinematic profiles. The study aims to address a critical gap in contemporary physiological monitoring - the inability to quantify labored breathing, which contains vital prognostic information not captured by conventional monitoring. Building on a recent innovation called ARK...
- This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $656,750 to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to advance the use of Electrical Impedance Tomography (EIT) for measuring lung perfusion in patients with Acute Respiratory Distress Syndrome (ARDS). The project aims...
- This Project Grant award from the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) aims to develop a modern Electrical Impedance Tomography (EIT) device for monitoring children in the Intensive Care Unit (ICU). The $299,900 award to Goodlife Inventors LLC will fund efforts to (1) generate initial designs for an advanced lightweight EIT belt and (2) assess the technical feasibility of a miniaturized, easier to use EIT core device. If...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $106,391 to the University of Colorado-Denver to investigate the role of developmental dysanapsis in lung development over the lifespan in an experimental bronchopulmonary dysplasia (BPD) model. The research aims to determine whether intra-amniotic endotoxin causes persistent dysanaptic growth of the airways, distal parenchyma, and vasculature in BPD, and...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $269,922 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Steth X Microsystems Inc. to develop a smart, wearable contact microphone patch for extended and remote monitoring of lung functions. The goal is to create a low-profile, battery-powered wireless device capable of accurately detecting and quantifying adventitious lung sounds as well as breathing abnormalities in patients with respiratory...
- This Project Grant award of $108,003.00, provided by the National Heart Lung and Blood Institute under CFDA Program 93.837 Cardiovascular Diseases Research, supports a study on "Early Changes of T2* Measures in Lung Tissues Using Deltate-UTE MRI on Healthy and COPD Patients" at the University of California, San Diego (UCSD). The goal is to develop an advanced ultrashort echo-time (UTE) magnetic resonance imaging (MRI) technique, called TE-UTE, to accurately map T2* values in lung...
- The University of Florida received a $149,348 Project Grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to conduct research on the cellular mechanisms of acute-intermittent hypercapnic-hypoxia induced phrenic motor plasticity. The project will monitor phrenic nerve activity in anesthetized rats as a proxy for respiratory motor output, with the goal of enhancing understanding of the pathways involved in phrenic long-term facilitation (PLTF)...
- This federal Project Grant award, valued at $518,613.00 and granted by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research), supports research to define the molecular basis of thrombospondin-1-induced fibro-fatty diaphragm remodeling, a driver of obesity-associated respiratory dysfunction. The research, conducted by the Regents of the University of Michigan, aims to investigate the role of the matricellular protein thrombospondin-1 in promoting...
- This Project Grant award for $702,103 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to systematically define the signaling pathways by which the protein SFTA2 interacts with the receptor ADGRF5 to control pulmonary surfactant homeostasis. The awardee, National Jewish Health, a non-profit research center in Colorado, will use cell-based assays and mouse genetics to test the hypothesis that SFTA2 regulates alveolar surfactant...
- The National Heart, Lung, and Blood Institute (NHLBI), through the Cardiovascular Diseases Research federal grant program (CFDA 93.837), awarded a $234,000 Project Grant to the University of Colorado-Denver. This 2-year grant, effective August 1, 2025 through July 31, 2027, will support secondary analysis of noninvasive imaging biomarkers to predict the early onset of single ventricle heart disease (SVD) failure. The research aims to quantify systemic and pulmonary vascular compliance through...
The National Heart, Lung, and Blood Institute (NHLBI), under CFDA Program 93.837 Cardiovascular Diseases Research, awarded a $655,885 Project Grant to Colorado State University (CSU) to study the use of Electrical Impedance Tomography (EIT) as a non-invasive measure of lung function in patients with muscular dystrophies. The project aims to evaluate the effectiveness of EIT as a surrogate for sleep studies in monitoring respiratory function and determining the optimal timing for initiating non-invasive ventilatory support. The award, with an effective date of September 15, 2025 and an ultimate completion date of June 30, 2030, will support research to compare EIT measures across different muscular dystrophy types and validate its use as an objective assessment tool to inform clinical decisions for respiratory support.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $655.9k | 9/12/25 |