This $123,424 Project Grant awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will support research at the University of California, Davis to map the cellular impacts of CHD8 haploinsufficiency and characterize microglial activity in CHD8 mutant mice. The project aims to elucidate the cell-specific transcriptomic mechanisms associated with CHD8 haploinsufficiency and...
This $237,750 Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), will support a research study conducted by the University of California, Merced. The study aims to elucidate the neurodevelopmental functions of the SMARCC2 gene and the Brahma Associated Factor (BAF) chromatin remodeling complex, which have been strongly implicated in autism spectrum disorders (ASD). Specifically, the research will investigate how...
This $504,283 federal Project Grant was awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant will fund a prospective cohort study examining the etiology of autism spectrum disorder (ASD) in children born preterm compared to term-born children. The study aims to: 1) Determine the epidemiology of ASD in preterm children and identify associated risk factors; 2) Estimate...
This federal Project Grant award, titled "Longitudinal Investigation of Bilingualism, Executive Function, and Brain Organization in Autism," was made by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The 5-year, $691,353 grant will support a longitudinal study examining the impact of bilingualism on executive function abilities and brain organization in children with autism...
This federal Project Grant award of $253,500.00 from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to resolve the relationship between mitochondrial dysfunction and the impact of non-syndromic autism spectrum disorder (ASD)-related risk genes on neuronal structure and function. The key products or services to be delivered through this grant include: (1) establishing...
This Project Grant award from the National Institute of Mental Health (NIMH) under CFDA Program 93.242 - Mental Health Research Grants provides $682,470 to the University of California, Los Angeles (UCLA) to elucidate the regulation of cell fate specification in human cortical development. The goal is to better understand the etiology of neurodevelopmental disorders. The research will evaluate the signals that drive cortical arealization and laminar identity using bioinformatic and CRISPR...
The National Institute of Child Health and Human Development (NICHD) awarded a $250,120 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to The Trustees of the University of Pennsylvania on August 23, 2024. This grant will support research to investigate the role of a specific histone gene mutation (MACROH2A1) in causing rare pediatric neurodevelopmental disorders. The research aims to 1) characterize the impact of this mutation on human neurodevelopment using...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $2,058,873.00 to Kaiser Foundation Hospitals to conduct research on the relationship between maternal autoantibodies, gestational inflammation, and child neurodevelopment. The key objectives are to: 1) examine maternal risk profiles related to the presence of maternal autoantibodies during pregnancy that...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under CFDA 93.865 Child Health and Human Development Extramural Research program, provides $1,723,657 to the University of California, Los Angeles (UCLA) to investigate the role of X-chromosome dosage compensation in regulating the feto-maternal interface within the placenta. The key research objectives are to: 1) further define the function of the XIST B-repeat in the placenta, 2) explore...
This $499,055.48 federal Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) supports research to identify novel noncoding mechanisms of disease associated with developmental disorders (DDs). The key objectives are to: (1) define novel candidate long-range positional effect loci by identifying topologically associated domains (TADs) intolerant to disruption and building models to predict...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $756,565.44 to the University of California, Los Angeles (UCLA) to conduct research on functional analysis of histone modifier autism spectrum disorders risk genes in vertebrate development. The award period runs from August 1, 2024 to July 31, 2027. The research efforts under this grant aim to explore critical biological mechanisms and potential therapeutic interventions related to autism spectrum disorders, leveraging UCLA's expertise in neuroscience, developmental biology, and translational research. This project grant is part of NICHD's broader portfolio of research focused on understanding fundamental health processes, growth, development, and population dynamics, with the goal of improving child and maternal health outcomes.