Project Grant R00GM151479
- This federal Project Grant award of $294,147 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) aims to advance modeling of macromolecular interactions in living cells. The key products and services to be delivered through this 5-year project (6/1/2025 - 5/31/2030) include: Characterization of the intermolecular energy landscapes for different types of macromolecules Simulation of macromolecular interactions...
- This Project Grant award of $249,000.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) is to support research at Duke University to expand the capabilities of enzymes beyond their natural functions for synthesizing medicinally important chemical compounds. The key products or services to be delivered include engineering heme enzymes and methionine sulfoxide reductases to catalyze aminations and oxidations,...
- This federal Project Grant award of $386,617 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) aims to develop safer and more efficient chemical methods for the synthesis of complex, fluorinated, and highly functional pharmaceutical compounds. The key research areas encompass: (1) electromicellar catalysis for the formation of fluorinated heterocycles, allenes, and reactive intermediates; (2) enantioselective...
- This $412,632 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to advance the biocatalytic synthesis of complex medicinal small molecules. The award, with a performance period from August 1, 2025 to July 31, 2030, will fund the development of computer-aided synthesis planning (CASP) tools to generalize known enzymatic reactions and predict routes for producing...
- This federal Project Grant award of $524,400.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The funding supports research at the Scripps Research Institute in La Jolla, CA to develop novel chemical transformations and catalysts that enable the efficient synthesis of structurally complex small molecules for drug discovery. The research aims to address challenges in organic synthesis by...
- This Project Grant award, totaling $410,849.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports a comprehensive strategy for advancing novel methodologies and innovative strategies for the chemical synthesis of intricate, bioactive alkaloid natural products derived from the Veratrum and Hapalindole families, among others. The research plan is divided into three distinct...
- The federal Project Grant award of $420,066.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will fund research to systematically characterize how regulatory networks control secondary metabolism in microbes. The project aims to use genome-wide screens and multi-omics approaches to predict and access the unexplored biosynthetic potential of microbes, with the goal of accelerating the discovery,...
- This federal Project Grant award for $874,000.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research on enantioselective and site-selective C-H activation reactions. The key objectives are to develop next-generation ligands capable of enantio- and site-selective C(SP3)-H activation of aliphatic carboxylic acid substrates, as well as to achieve enantio- and site-selective ring...
- This federal Project Grant award of $401,595 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research on labdane-related diterpenoid biosynthesis at Iowa State University. The project aims to build on the university's previous work investigating the enzymes required to produce these natural products, which have potential pharmaceutical and agricultural applications. The award will enable further...
- This federal Project Grant award, valued at $456,500.00 and provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), is focused on decoding the biosynthetic logic of modular polyketide synthases (PKSs). PKSs are enzymatic assembly lines that produce complex small molecules with medicinal importance, such as antibiotics, anticancer agents, and lipid-lowering statins. The key objectives of this research...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), totals $249,000.00 and will be performed from September 1, 2025 to July 31, 2028. The award supports research at the University of Kansas Center for Research Inc. aimed at developing chemoenzymatic approaches for synthesizing biologically active small molecules. Key objectives include enabling the preparation of polyhydroxylated tropolones with diverse bioactivities and expediting the synthesis of spirocyclic tropolone natural products. The research will also investigate hidden reaction pathways across enzyme families, focusing initially on amino acid functionalization using native pyridoxal phosphate-dependent enzymes. This multifaceted project leverages biocatalysts from bacterial and fungal tropolone biosynthesis as well as cytochrome P450 enzymes to advance synthetic capabilities in the production of therapeutic and bioactive compounds.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $249.0k | 8/26/25 |