This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) is focused on developing an injectable hydrogel biomaterial to improve the survival and integration of human induced pluripotent stem cell-derived neurons (hiPSC-neurons) transplanted into the site of spinal cord injuries. The $504,888 award, spanning from June 2024 to April 2027,...
This federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" program (CFDA 93.286) provides $207,900.00 to The Leland Stanford Junior University to develop a three-cell synthetic immunotherapy system. The project aims to engineer T cells, natural killer (NK) cells, and macrophages to express chimeric antigen receptors (CARs) and synthetic...
This federal Project Grant award, valued at $1,404,189.00, was provided by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" (CFDA 93.286) program. The award, with a start date of June 1, 2024 and an ultimate completion date of February 29, 2028, is being used by William Marsh Rice University to develop new capabilities for engineering human cells using robust and...
This federal Project Grant award of $359,995 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" program (CFDA 93.286) supports the development and validation of a novel X-ray visualized immunosensor device. The goal is to fabricate and validate this immunosensor to detect and monitor local infection biomarker concentrations in implanted medical devices using...
This Project Grant award of $1,227,600.00 was provided by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" (CFDA 93.286) program. The grant supports the development of a remotely coupled and injectable antenna system to enable wireless biotelemetry for next-generation implantable medical devices. The research aims to create a new class of implantable antennas that can...
This $241,823 federal Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) supports the development of an implantable engineered tissue with optogenetically engineered human beta-cells. The project aims to address challenges in creating vascularized tissues with light-activatable cells to improve treatment for diabetes. Key activities include designing a gelatin-based engineered tissue with oxygen-generating microparticles and optogenetically...
This Project Grant award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $305,000 to Novaurum Biosciences Incorporated to develop a novel mammalian cell-based nano-biological coating for implantable medical devices. The goal is to address the critical health and economic burden associated with implant-related infections by creating a biocompatible and antimicrobial coating that can limit biofilm formation and protect...
This Project Grant award of $1,158,000 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) supports research at Stanford University focused on understanding and engineering cellular recognition and multicellular organization for cancer immunotherapy applications. The research aims to advance the use of engineered T cells for targeting solid tumors by exploring mechanisms to enhance T cell specificity and...
This Project Grant award from the Trans-NIH Research Support program, CFDA #93.310, provides $1,350,770 to The Leland Stanford Junior University to develop a novel class of synthetic RNA-based receptors to enhance the targeting precision of mRNA-mediated adoptive cell therapies. The project aims to create a modular, programmable receptor system that can convert ligand-induced dimerization events into the expression of desired output proteins, enabling improved specificity for ablating target...
The National Science Foundation (NSF) awarded a three-year, $449,999 Project Grant under their Engineering program (CFDA 47.041) to the University of Cincinnati to develop an implantable biosensor platform that can continuously monitor various biomarkers in the body for over a year. The project aims to create a new class of long-lasting aptamer-based sensors protected by robust porous oxide coatings, which would enable the first practical implantable monitoring system for managing chronic...